Is Butyl Propionate safe in cosmetics?
Butyl Propionate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Butyl Propionate
Also known as: Propanoic acid, butyl ester, 4-02-00-00708, BRN 1700932, Butyl propanoate, n-Butyl propanoate (+10 more)
INCI: BUTYL PROPIONATE
Butyl Propionate (CAS 590-01-2) is a cosmetic cosmetic ingredient functioning as Solvent; fragrance ingredient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 590-01-2 →
Auto-generated CPSR Part A draft with source citations
Function
Solvent; fragrance ingredient
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
butyl propanoate
InChIKey
BTMVHUNTONAYDX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Likely adequate at typical fragrance use levels (<1%); formal MoS calculation recommended
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Butyl Propionate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The vapour is irritating to the respiratory tract.
Routes of Exposure
The substance can be absorbed into the body by inhalation.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 1350 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
0556
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Regulatory (2)
JECFA Number
143
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
BUTYL PROPIONATE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/52 | FAS 40-JECFA 49/297
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Solvent
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Butyl Propionate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
Propanoic acid, butyl ester
4-02-00-00708
BRN 1700932
Butyl propanoate
n-Butyl propanoate
EINECS 209-669-5
FEMA No. 2211
NSC 8449
UNII-2NXC4AK99E
Butyl ester of propanoic acid
Butyl propionate [UN1914] [Flammable liquid]
FEMA 2211
N-Butyl N-propionate
N-Butyl propionate
Propionic acid, butyl ester
Chemical Function
Fragrance
Flavouring and nutrient
Solvent
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
air; detected; emissions; Europe; Other direct contact consumer goods
air; emissions; Europe; nondetect; Other direct contact consumer goods
Arts and crafts/Office supplies - fabric treatment and dye; detected
air; detected; emissions; Europe; Other direct contact consumer goods
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3561586
Frequently Asked Questions
Is Butyl Propionate allowed in the EU?
Butyl Propionate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Butyl Propionate do in cosmetics?
Butyl Propionate functions as: Solvent; fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 590-01-2.
Is Butyl Propionate used outside cosmetics?
Butyl Propionate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Butyl Propionate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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