Also known as: Edetic acid, Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, EDTA, BRN 1716295, Caswell No. 438 (+15 more)
CAS 60-00-4
Ethylenediaminetetraacetic acid (CAS 60-00-4) is a chemical substance with GHS signal word Warning; key hazard signal: H319. Key regulatory status: REACH registered, 21 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Eye Irrit. 2 | H319 | GHS07 | Warning |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | May be harmful if swallowed Causes eye irritation |
| Short-term Effects | The substance is irritating to the eyes. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of dust, by inhalation of its aerosol and by ingestion. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - body hygiene - body wash | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Specialty occupational products | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; wastewater | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| inert_ingredient; Pesticides | EPA | CPCat |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1.5 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 9G34HU7RV0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9G34HU7RV0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9G34HU7RV0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9G34HU7RV0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =15 | % | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =400 | ppm | NOEL | oral | Rat | ToxValDB_ECOTOX |
| =1200 | ppm | NOEL | oral | Rat | ToxValDB_ECOTOX |
Showing 8 of 8 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Edetic acid | 200-449-4 | ECHA overview → |
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Ethylenediaminetetraacetic acid (CAS 60-00-4) is classified under EU CLP Annex VI as Eye Irrit. 2 with signal word Warning. Hazard statements: H319. Source: EU CLP Annex VI (ECHA).
Ethylenediaminetetraacetic acid has 8 NOAEL studies in the database. The lowest reported value is 1.5 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Ethylenediaminetetraacetic acid appears on 16 regulatory/inventory lists including pharmaceutical, Canada; pharmaceutical, active_ingredient; Pesticides, and 13 more. Source: EPA CPDat.
Yes, Ethylenediaminetetraacetic acid is also indexed as a cosmetic ingredient under the name EDTA. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Ethylenediaminetetraacetic acid also appears in cosmetics, pharmaceutical databases.