EDTA
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for EDTA. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=938 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | >=500 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=500 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=500 mg/kg bw/day | oral | - | oral | REACH |
| NOAEL | 1125 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Expert Verdict
Safe as used at conventional cosmetic concentrations (less than 0.5% leave-on); not permitted in COSMOS/ECOCERT formulations; penetration-enhancement effect on co-ingredients is key formulator risk.
Regulatory Flags
Frequently Asked Questions
Is EDTA safe in cosmetics?
Safe as used at conventional cosmetic concentrations (less than 0.5% leave-on); not permitted in COSMOS/ECOCERT formulations; penetration-enhancement effect on co-ingredients is key formulator risk. The EU classifies EDTA as "permitted". Safety rating: GOOD. 5 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Is EDTA allowed in the EU?
EDTA EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does EDTA do in cosmetics?
EDTA functions as: Chelating. It is classified as a cosmetic ingredient in our database. CAS number: 60-00-4.
What is the Margin of Safety for EDTA?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for EDTA?
The NOAEL (No Observed Adverse Effect Level) for EDTA is >=938 mg/kg bw/day based on a oral study via oral route in mouse. A total of 5 study endpoints are available. Source: REACH.
Is EDTA classified as hazardous under GHS?
EDTA carries a GHS signal word of "WARNING". Hazard statements: May be harmful if swallowed Causes eye irritation. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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Related Ingredients
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