What is the NOAEL for Glycerol tributyrate?
Glycerol tributyrate has 29 NOAEL studies in the database. The lowest reported value is S05LZ624MF UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Glycerol tributyrate
Also known as: 4-02-00-00799, BRN 1714746, Butyric acid triester with glycerin, EINECS 200-451-5, FEMA No. 2223 (+4 more)
CAS 60-01-5
Glycerol tributyrate (CAS 60-01-5) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
SOURCE
noael studies public
NOAEL studies
29
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
Glycerol tributyrate
CAS Number
60-01-5
DTXSID
DTXSID4052267
Molecular Formula
C15H26O6
InChI Key
UYXTWWCETRIEDR-UHFFFAOYSA-N
Monoisotopic Mass
302.172939
Synonyms
4-02-00-00799BRN 1714746Butyric acid triester with glycerinEINECS 200-451-5FEMA No. 22231,2,3-Propanetriyl tributanoateTributyrinineTributyrl glycerideUNII-S05LZ624MF
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Flavouring and nutrientSolvent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Europe | European Commission | Fl@vis |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 29 of 29 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| S05LZ624MF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S05LZ624MF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S05LZ624MF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S05LZ624MF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =3200 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =50 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =50 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =125 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =125 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =125 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >219 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >219 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >219 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >300 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >300 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =340 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =340 | mg/kg bw/day | NOAEL | oral: drinking water | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =340 | mg/kg bw/day | NOAEL | oral: drinking water | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >1000 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >1000 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >1450 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >1450 | mg/kg bw/day | NOAEL | oral: drinking water | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >1450 | mg/kg bw/day | NOAEL | oral: drinking water | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >2500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >2500 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >2500 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Showing 29 of 29 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
TRIBUTYRIN
ChEMBL Phase
1
Adverse Events
3
Bioactivity
2
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Glycerol tributyrate?
Glycerol tributyrate appears on 3 regulatory/inventory lists including food_additive; Substances Added to Food (formerly EAFUS) (2/2019), Europe, Canada; pharmaceutical. Source: EPA CPDat.
Is Glycerol tributyrate used in cosmetics?
Yes, Glycerol tributyrate is also indexed as a cosmetic ingredient under the name Glyceryl Tributyrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Glycerol tributyrate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Glycerol tributyrate used outside industrial chemicals?
Glycerol tributyrate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.