Is Glyceryl Tributyrate safe in cosmetics?
Glyceryl Tributyrate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Glyceryl Tributyrate
Also known as: 4-02-00-00799, BRN 1714746, Butyric acid triester with glycerin, EINECS 200-451-5, FEMA No. 2223 (+4 more)
INCI: GLYCERYL TRIBUTYRATE
Glyceryl Tributyrate (CAS 60-01-5) is a cosmetic cosmetic ingredient functioning as Emollient, Emulsifying, Flavoring. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 60-01-5 →
Auto-generated CPSR Part A draft with source citations
Function
Emollient, Emulsifying, Flavoring
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2,3-di(butanoyloxy)propyl butanoate
InChIKey
UYXTWWCETRIEDR-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Used in cosmetics and pharmaceuticals; also a food-approved flavoring agent (GRAS in food context)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Glyceryl Tributyrate.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (4)
JECFA Number
922
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
BUTYRIN | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/112 | FAS 48-JECFA 57/333
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
GLYCERYL TRIBUTYRATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/112 | FAS 48-JECFA 57/333
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
TRIBUTYRIN | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/112 | FAS 48-JECFA 57/333
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Solvent
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Glyceryl Tributyrate.
Regulatory Flags
emollient
triglyceride
butyric-acid-derived
food-grade-safety
fda_food_additive
Known Synonyms
4-02-00-00799
BRN 1714746
Butyric acid triester with glycerin
EINECS 200-451-5
FEMA No. 2223
1,2,3-Propanetriyl tributanoate
Tributyrinine
Tributyrl glyceride
UNII-S05LZ624MF
Chemical Function
Flavouring and nutrient
Solvent
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
TRIBUTYRIN
ChEMBL ID
CHEMBL118722
Max Phase
1
Adverse Event Associations
3
Frequently Asked Questions
Is Glyceryl Tributyrate allowed in the EU?
Glyceryl Tributyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Glyceryl Tributyrate do in cosmetics?
Glyceryl Tributyrate functions as: Emollient, Emulsifying, Flavoring. It is classified as a cosmetic ingredient in our database. CAS number: 60-01-5.
Is Glyceryl Tributyrate used outside cosmetics?
Glyceryl Tributyrate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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