NOAEL Data REACH Registered Cosmetic Ingredient

2-Phenylethanol

Also known as: Benzeneethanol, 4-06-00-03067, Benzylmethanol, BRN 1905732, Caswell No. 655C (+15 more)

CAS 60-12-8

2-Phenylethanol (CAS 60-12-8) is a chemical substance. Key regulatory status: REACH registered, 17 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Phenylethyl Alcohol →

Cross-Vertical Regulatory Divergence

2-Phenylethanol is classified GHS Danger (H302, H319, H311, H336, H361, H371, H318) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields

Name

2-Phenylethanol

CAS Number

60-12-8

Molecular Formula

C8H10O

InChI Key

WRMNZCZEMHIOCP-UHFFFAOYSA-N

Monoisotopic Mass

122.073165

Synonyms

Benzeneethanol4-06-00-03067BenzylmethanolBRN 1905732Caswell No. 655CEINECS 200-456-2EPA Pesticide Chemical Code 001503FEMA No. 2858FEMA Number 2858beta-Hydroxyethylbenzene2-HydroxyethylbenzeneMethanol, benzyl-

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Harmful if swallowed Toxic in contact with skin Causes skin and eye irritation Suspected of damaging fertility or the unborn child May be harmful if swallowed and enters airways
Short-term Effects	The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis.
Long-term Effects	Animal tests show that this substance possibly causes toxicity to human reproduction or development.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its aerosol or vapour, through the skin and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

FragranceDeodorizerNo specific technical functionPreservativeFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 17 records

List	Keyword	Source
Europe	European Commission	Fl@vis
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List
Canada; pharmaceutical	DrugBank	DrugBank
Australia; Food and drug - smoking-related products	New Zealand ESR	CPCat
IFRA Transparency	IFRA	IFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
consumer_product	P&G	Proctor & Gamble
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
detected; Europe; Personal care - sexual wellness	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - nails - nail polish	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe	Danish Environmental Protection Agency	Danish EPA
Canada; pharmaceutical	DrugBank	DrugBank
Europe; Pesticides	Danish EPA	Danish EPA
detected; Europe; Pesticides	Danish EPA	Danish EPA
Cleaning products and household care - air freshener; Europe	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 57 studies

Value	Unit	Endpoint	Route	Species	Source
21.6	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
37.08	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
62.5	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
4	%	Concentration, one positive response	Dermal	Human	NTP ICE skin sensitization
8.333	%	Concentration, one positive response	Dermal	Human	NTP ICE skin sensitization
25	%	Concentration, one positive response	Dermal	Human	NTP ICE skin sensitization
=59.9	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
ML9LGA7468	UNII	FDA UNII substance identifier	-	-	openFDA substances
0	%	Incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
1.852	%	Incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
2	%	Incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
3.371	%	Incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
2756	ug/cm2	Induction dose per skin area	Dermal	Human	NTP ICE skin sensitization
4966	ug/cm2	Induction dose per skin area	Dermal	Human	NTP ICE skin sensitization
1.039e+4	ug/cm2	Induction dose per skin area	Dermal	Human	NTP ICE skin sensitization
1.550e+4	ug/cm2	Induction dose per skin area	Dermal	Human	NTP ICE skin sensitization
4087	ug/cm2	Induction dose per skin area, 5% incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
6889	ug/cm2	Induction dose per skin area, 5% incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
2.806e+4	ug/cm2	Induction dose per skin area, 5% incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
918.5	ug/cm2	Induction dose per skin area, one positive response	Dermal	Human	NTP ICE skin sensitization
5197	ug/cm2	Induction dose per skin area, one positive response	Dermal	Human	NTP ICE skin sensitization
>0.5	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
=125	mg/kg bw/day	LEL	oral	Chicken	EFSA
=4.3	mg/kg bw/day	LOAEL	oral	Rat	ECHA
4.3	mg/kg bw/day	LOAEL	oral	rat	COSMOS DB
=143	mg/kg bw/day	LOAEL	dermal	Rat	ECHA
=508	mg/kg bw/day	LOAEL	oral	Rat	ECHA
0	unitless	Model Score	-	-	NTP ICE endocrine
4.3	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
=43	mg/kg bw/day	NOAEL	oral	Rabbit	ECHA
~50	mg/kg bw/day	NOAEL	oral	Rabbit	ECHA
51	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
=70	mg/kg bw/day	NOAEL	dermal	Rat	ECHA
=140	mg/kg bw/day	NOAEL	dermal	Rat	ECHA
=430	mg/kg bw/day	NOAEL	dermal	Rat	ECHA
=439	mg/kg bw/day	NOAEL	dermal	Rat	ECHA
=510	mg/kg bw/day	NOAEL	dermal	Rat	ECHA
=799	mg/kg bw/day	NOAEL	oral	Rat	ECHA
2500	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
=15	mg/kg bw/day	NOEL	-	-	WHO/JECFA
=250	mg/kg bw/day	NOEL	-	-	WHO/JECFA
=380	mg/kg bw/day	NOEL	-	-	WHO/JECFA
2	unitless	Relative reliability score	Dermal	Human	NTP ICE skin sensitization
3	unitless	Relative reliability score	Dermal	Human	NTP ICE skin sensitization
77.8	%	Viability	Dermal	-	NTP ICE skin irritation
92.55	%	Viability	Dermal	-	NTP ICE skin irritation
95.99	%	Viability	Dermal	-	NTP ICE skin irritation
98.16	%	Viability	Dermal	-	NTP ICE skin irritation
91.5	%	Viability (240 minutes)	Dermal	-	NTP ICE skin irritation
100.1	%	Viability (240 minutes)	Dermal	-	NTP ICE skin irritation

Showing 50 of 57 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	2-phenylethanol	200-456-2	ECHA overview →

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed PHENYLETHYL ALCOHOL

ChEMBL Phase

-1

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for 2-Phenylethanol?

2-Phenylethanol has 57 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.

What regulatory lists include 2-Phenylethanol?

2-Phenylethanol appears on 15 regulatory/inventory lists including Europe, active_ingredient; Europe; Pesticides, SCIL (9/2019), and 12 more. Source: EPA CPDat.

Is 2-Phenylethanol used in cosmetics?

Yes, 2-Phenylethanol is also indexed as a cosmetic ingredient under the name Phenylethyl Alcohol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Phenylethanol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Phenylethanol have different safety status in cosmetics vs industrial chemicals?

2-Phenylethanol is classified GHS Danger (H302, H319, H311, H336, H361, H371, H318) in the chemicals database but is allowed in EU cosmetics.

Is 2-Phenylethanol used outside industrial chemicals?

2-Phenylethanol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.