Good Cosmetic Ingredient NOAEL Data GHS Classified

Phenylethyl Alcohol

INCI: PHENETHYL ALCOHOL

Phenylethyl Alcohol (CAS 60-12-8) is a cosmetic cosmetic ingredient functioning as Fragrance, Antimicrobial Preservative, Masking Agent, Preservative Booster. NOAEL 510 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.

View industrial chemical safety profile for CAS 60-12-8 →

Auto-generated CPSR Part A draft with source citations

CAS Number

60-12-8

View industrial chemical safety profile →

Function

Fragrance, Antimicrobial Preservative, Masking Agent, Preservative Booster

Safety Rating

GOOD

Chemistry & Identifiers

Formula

C8H10O

122.16 g/mol

EC Number

200-456-2

PubChem CID

6054

IUPAC Name

2-phenylethanol

InChIKey

WRMNZCZEMHIOCP-UHFFFAOYSA-N

ChEBI: CHEBI:49000 UNII: ML9LGA7468 Wikidata: Q209463

Regulatory Status

EU EU Status permitted

US US Status permitted

US Notes FEMA GRAS No. 2858; CIR safe up to 1.0%; no FDA cosmetic concentration limits

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Phenylethyl Alcohol.

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

8 study endpoints found for Phenylethyl Alcohol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	51 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
NOAEL	=43 mg/kg bw/day	oral	Rabbit	reproduction developmental	ToxValDB_ECHA_IUCLID
NOAEL	=70 mg/kg bw/day	dermal	Rat	developmental	ToxValDB_ECHA_IUCLID
NOAEL	=140 mg/kg bw/day	dermal	Rat	developmental	ToxValDB_ECHA_IUCLID
NOAEL	=430 mg/kg bw/day	dermal	Rat	reproduction developmental	ToxValDB_ECHA_IUCLID
NOAEL	=439 mg/kg bw/day	dermal	Rat	developmental	ToxValDB_ECHA_IUCLID
NOAEL	=510 mg/kg bw/day	dermal	Rat	subchronic	ToxValDB_ECHA_IUCLID
NOAEL	=799 mg/kg bw/day	oral	Rat	developmental	ToxValDB_ECHA_IUCLID

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word

DANGER

Pictograms

SkullToxicCancerHealth haz

Hazard Statements

Harmful if swallowed Toxic in contact with skin Causes skin and eye irritation Suspected of damaging fertility or the unborn child May be harmful if swallowed and enters airways

Short-term Exposure Effects

The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis.

Long-term Exposure Effects

Animal tests show that this substance possibly causes toxicity to human reproduction or development.

Routes of Exposure

The substance can be absorbed into the body by inhalation of its aerosol or vapour, through the skin and by ingestion.

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for Phenylethyl Alcohol across SCCS product categories, with measured dermal absorption where available.

EPA ToxValDB — Toxicity Values

10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).

Endpoint	Value	Species	Route	Duration	Source
LEL	=125 mg/kg-day	Chicken	oral	subchronic	EFSA
LEL	=125 mg/kg-day	Pig	oral	subchronic	EFSA
LEL	=125 mg/kg-day	Cow Family	oral	subchronic	EFSA
LD50	=0.79 mL/kg bw	Rabbit	dermal	-	ECHA IUCLID
LD50	=2.46 mL/kg bw	Rat	oral	-	ECHA IUCLID
LOAEL	=508 mg/kg-day	Rat	oral	-	ECHA IUCLID
LOAEL	=508 mg/kg-day	Rat	oral	-	ECHA IUCLID
LOAEL	=4.3 mg/kg-day	Rat	oral	-	ECHA IUCLID
LOAEL	=4.3 mg/kg-day	Rat	oral	-	ECHA IUCLID
LOAEL	=4.3 mg/kg-day	Rat	oral	-	ECHA IUCLID

Sensitization AOP Dashboard

Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.

NESIL

2756 µg/cm²

GHS: 1B Human: positive

Source: HPPT: [103] Greif N (1967): Cutaneous safety of fragrance material as measured by the maximization test.

HRIPT Human Patch Test Studies

4 human repeat insult patch tests aggregated from dermatological literature.

Test Type	N	Dose µg/cm²	NESIL µg/cm²	Potency
HMT	-	4965.52	-	-
HRIPT	-	10393.7	-	-
HRIPT	-	2755.56	-	-
HRIPT	-	15500.03	-	-

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type

Full

Tonnage Band

1,000 - 10,000 tonnes

Substance Type

SUBSTANCE

SVHC Candidate

Expanded Jurisdictional Detail

Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.

BRIN Brazil/India Cosmetics

Brazil: Permitted Preservative · max 1,0%

Additional Jurisdictional Restrictions (2)

Jurisdiction	Status	Max %	Product Type
CN	permitted_preservative	1	All cosmetics
BR	permitted_preservative	1	-

Expanded Dermal Absorption Data

Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.

Roberts Skin Permeation (Mendeley 2022)

MW: 122.2

Log Kow: 1.36

Log Kp: -2.115272505103307

Log Jmax: -5.86

Source: Roberts_Cheruvu_Mendeley_2022

PubChem Annotations

Safety and regulatory annotations from PubChem (NCBI) aggregated sources.

Safety (2)

Endocrine Disruptors

Potential endocrine disrupting compound

Source: NORMAN Suspect List Exchange

ICSC Safety Card

0936

Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Regulatory (8)

JECFA Number

987