What is the NOAEL for L-Tyrosine?
L-Tyrosine has 11 NOAEL studies in the database. The lowest reported value is 42HK56048U UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
L-Tyrosine
Also known as: Tyrosine, (S)-alpha-Amino-4-hydroxybenzenepropanoic acid, alpha-Amino-4-hydroxybenzenepropanoic acid, (S)-, alpha-Amino-p-hydroxyhydrocinnamic acid, (-)-, L-2-Amino-3-p-hydroxyphenylpropanoic acid (+15 more)
CAS 60-18-4
L-Tyrosine (CAS 60-18-4) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
L-Tyrosine
CAS Number
60-18-4
DTXSID
DTXSID1023730
Molecular Formula
C9H11NO3
InChI Key
OUYCCCASQSFEME-QMMMGPOBSA-N
Monoisotopic Mass
181.073893
Synonyms
Tyrosine(S)-alpha-Amino-4-hydroxybenzenepropanoic acidalpha-Amino-4-hydroxybenzenepropanoic acid, (S)-alpha-Amino-p-hydroxyhydrocinnamic acid, (-)-L-2-Amino-3-p-hydroxyphenylpropanoic acid2-Amino-3-(4-hydroxyphenyl)propanoic acid, (S)-alpha-Amino-beta-(4-hydroxyphenyl)propionic acidBenzenepropanoic acid, alpha-amino-4-hydroxy-, (S)-EINECS 200-460-4FEMA No. 3736beta-(p-Hydroxyphenyl)alanineTyrosinum
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
15 records
Anti-static agentDeodorizerSoftener and conditionerFragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 42HK56048U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 42HK56048U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 42HK56048U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 42HK56048U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =200 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =600 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 618 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 5000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 8000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Tyrosine | 200-460-4 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Amino Acid
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
TYROSINE
ChEMBL Phase
4
Adverse Events
8
Bioactivity
4
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include L-Tyrosine?
L-Tyrosine appears on 6 regulatory/inventory lists including Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), pharmaceutical, and 3 more. Source: EPA CPDat.
Is L-Tyrosine used in cosmetics?
Yes, L-Tyrosine is also indexed as a cosmetic ingredient under the name L-Tyrosine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for L-Tyrosine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is L-Tyrosine used outside industrial chemicals?
L-Tyrosine also appears in cosmetics, pharmaceutical, cannabis databases.