Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for L-Tyrosine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 618 mg/kg bw/day | oral | rat | Neurotoxicity | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 8000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Neurotoxicity | COSMOS_DB |
Expert Verdict
Aromatic amino acid with dual skin activity: activates melanin synthesis in tanning products and inhibits tyrosinase for brightening in other formulations; antistatic and hair-conditioning properties also noted; safe for topical use
Regulatory Flags
Frequently Asked Questions
Is L-Tyrosine safe in cosmetics?
Aromatic amino acid with dual skin activity: activates melanin synthesis in tanning products and inhibits tyrosinase for brightening in other formulations; antistatic and hair-conditioning properties also noted; safe for topical use The EU classifies L-Tyrosine as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is L-Tyrosine allowed in the EU?
L-Tyrosine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does L-Tyrosine do in cosmetics?
L-Tyrosine functions as: Antistatic, Hair conditioning, Skin conditioning, Masking, Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 60-18-4.
What is the Margin of Safety for L-Tyrosine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for L-Tyrosine?
The NOAEL (No Observed Adverse Effect Level) for L-Tyrosine is 618 mg/kg bw/day based on a Neurotoxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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