Also known as: Ethane, 1,1'-oxybis-, Ethyl ether, EINECS 200-467-2, Ethyl ether, tech., RCRA waste number U117 (+10 more)
CAS 60-29-7
Diethyl ether (CAS 60-29-7) is a chemical substance with GHS signal word Danger; key hazard signal: H224; H302; H336. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC, OSHA.
Diethyl ether is prohibited in EU cosmetics but has active industrial GHS classifications (H224, H302, H336).
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 1; Acute Tox. 4 *; STOT SE 3 | H224; H302; H336 | GHS02; GHS07 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Extremely flammable liquid and vapour Harmful if swallowed May cause drowsiness or dizziness |
| Short-term Effects | The substance is mildly irritating to the eyes and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. The substance may cause effects on the central nervous system. This may result in narcosis. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the central nervous system. May cause addiction. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 400 ppm (1200 mg/m³) | 400 | 1200 | N |
| ACGIH | TWA | 400 ppm [1966] | 400 | - | N |
| ACGIH | STEL | 500 ppm [1966] | 500 | - | N |
| CAL/OSHA | TWA | 400 ppm (1200 mg/m³) | 400 | 1200 | N |
| CAL/OSHA | STEL | 500 ppm (1500 mg/m³) | 500 | 1500 | N |
| NIOSH | IDLH | 1900 ppm | 1900 | - | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Arts and crafts/Office supplies - fabric treatment and dye; Arts and crafts/Office supplies - home office - pens and markers; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =308 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 0F5N573A2Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0F5N573A2Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0F5N573A2Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0F5N573A2Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1200 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1213 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1215 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1600 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1700 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >3230 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3560 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| <3920 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =57601 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =30 | mg/L | LOAEL | inhalation | Guinea Pig | ToxValDB_HPVIS |
| =2000 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_HPVIS |
| =3031 | mg/m3 | LOAEL (HEC) | inhalation | Mouse | ToxValDB_PPRTV_(CPHEA) |
| =3 | mg/L | NOAEL | inhalation | Guinea Pig | ToxValDB_HPVIS |
| =6.2 | mg/L | NOAEL | inhalation | Rat | ToxValDB_HPVIS |
| =30 | mg/L | NOAEL | inhalation | Rat | ToxValDB_HPVIS |
| =303.163 | mg/m3 | NOAEL | inhalation | Human | ToxValDB_EU_SCOEL |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_MN_MDH_HHBW |
| =500 | mg/kg/day | NOAEL | oral | - | EPA_IRIS_iris_rfd_systems.csv |
| =3 | mg/m3 | RfC (provisional) | inhalation | Human | ToxValDB_PPRTV_(CPHEA) |
| =0.2 | mg/kg bw/day | RfD | oral | Human | ToxValDB_IRIS |
| =0.2 | mg/kg/day | RfD | oral | - | EPA_IRIS_iris_rfd_systems.csv |
| =0.5 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
Showing 28 of 28 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Diethyl ether | 200-467-2 | ECHA overview → |
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Diethyl ether (CAS 60-29-7) is classified under EU CLP Annex VI as Flam. Liq. 1; Acute Tox. 4 *; STOT SE 3 with signal word Danger. Hazard statements: H224; H302; H336. Source: EU CLP Annex VI (ECHA).
Diethyl ether has 28 NOAEL studies in the database. The lowest reported value is 308 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Diethyl ether appears on 4 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Arts and crafts/Office supplies - fabric treatment and dye; Arts and crafts/Office supplies - home office - pens and markers; detected; Europe, Canada; pharmaceutical, and 1 more. Source: EPA CPDat.
Occupational exposure limits for Diethyl ether are set by OSHA, ACGIH, CAL/OSHA. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Diethyl ether is also indexed as a cosmetic ingredient under the name Ethyl Ether. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Diethyl ether is prohibited in EU cosmetics but has active industrial GHS classifications (H224, H302, H336).
Diethyl ether also appears in cosmetics, pharmaceutical databases.