Moderate Cosmetic Ingredient NOAEL Data GHS Classified

Ethyl Ether

INCI: ETHYL ETHER

CAS Number

60-29-7

Function

Solvent

Safety Rating

MODERATE

Regulatory Status

🇪🇺 EU Status prohibited

🇺🇸 US Status permitted

US Notes Permitted — no specific CFR cosmetic prohibition; regulated by OSHA for occupational exposure (PEL 400 ppm); cited by ACGIH, DOT, NFPA, EPA

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)

not established

Dermal Absorption

moderate

Sensitization

none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for Ethyl Ether. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	500 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	500 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	100 mg/kg bw/day	oral	rabbit	oral	REACH
NOEL	20000 ppm	1995	rat	inhalation	REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word

DANGER

Pictograms

flam;flame; excl mark;warn

Hazard Statements

Extremely flammable liquid and vapour Harmful if swallowed May cause drowsiness or dizziness

Short-term Exposure Effects

The substance is mildly irritating to the eyes and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. The substance may cause effects on the central nervous system. This may result in narcosis.

Long-term Exposure Effects

The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the central nervous system. May cause addiction.

Routes of Exposure

The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Expert Verdict

⚠️

Concern Level: High

Regulatory Flags

jecfa_concern

Frequently Asked Questions

Is Ethyl Ether safe in cosmetics?

Extremely flammable (flash point −45°C); CNS depressant via inhalation; forms explosive peroxides on storage; GMP/safety nightmare for manufacturing; not realistic for commercial cosmetic products despite technical legality; inhalation risk in spray/aerosol applications The EU classifies Ethyl Ether as "prohibited". Safety rating: MODERATE. 4 toxicological study endpoint(s) are available in our database.

Is Ethyl Ether allowed in the EU?

Ethyl Ether EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Ethyl Ether do in cosmetics?

Ethyl Ether functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 60-29-7.

What is the Margin of Safety for Ethyl Ether?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Ethyl Ether?

The NOAEL (No Observed Adverse Effect Level) for Ethyl Ether is 500 mg/kg bw/day based on a oral study via oral route in rat. A total of 4 study endpoints are available. Source: REACH.

Is Ethyl Ether classified as hazardous under GHS?

Ethyl Ether carries a GHS signal word of "DANGER". Hazard statements: Extremely flammable liquid and vapour Harmful if swallowed May cause drowsiness or dizziness. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check Ethyl Ether compliance across multiple jurisdictions:

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Ingredient Decoder

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82 Allergen Checker

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Substance Compliance

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MoS Calculator

Calculate Margin of Safety using SCCS methodology

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Heavy Metal Limits

Compare limits across jurisdictions

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