NOAEL Data Cosmetic Ingredient

3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one

Also known as: 1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-, Propiophenone, 2',4',6'-trihydroxy-3-(p-hydroxyphenyl)-, 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone, EINECS 200-488-7, beta-(p-Hydroxyphenyl)phloropropiophenone (+5 more)

CAS 60-82-2

3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one (CAS 60-82-2) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.

View cosmetic safety profile for Phloretin Ingredient Analysis →

SOURCE noael studies public
NOAEL studies
4
SOURCE chemical inventory jurisdictions
Regulatory lists
3
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 16 fields
Name
3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
CAS Number
60-82-2
DTXSID
DTXSID6022393
Molecular Formula
C15H14O5
InChI Key
VGEREEWJJVICBM-UHFFFAOYSA-N
Monoisotopic Mass
274.084124
Synonyms
1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-Propiophenone, 2',4',6'-trihydroxy-3-(p-hydroxyphenyl)-3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanoneEINECS 200-488-7beta-(p-Hydroxyphenyl)phloropropiophenonebeta-(p-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone4,2',4',6'-TetrahydroxydihydrochalconeUNII-S5J5OE47MK4-O-MethylphloracetophenonePhloretin

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records
AntioxidantPharmaceuticalFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records
ListKeywordSource
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
EuropeEuropean CommissionFl@vis
Canada; pharmaceuticalDrugBankDrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 4 of 4 studies
ValueUnitEndpointRouteSpeciesSource
S5J5OE47MKUNIIFDA UNII substance identifier--openFDA substances
S5J5OE47MKUNIIFDA UNII substance identifier--openFDA substances
S5J5OE47MKUNIIFDA UNII substance identifier--openFDA substances
S5J5OE47MKUNIIFDA UNII substance identifier--openFDA substances

Showing 4 of 4 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
35.5%
Category
Other
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL PHLORETIN
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
8
View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one?

3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one has 4 NOAEL studies in the database. The lowest reported value is S5J5OE47MK UNII. Source: openFDA substances.

What regulatory lists include 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one?

3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one appears on 3 regulatory/inventory lists including food_additive; Substances Added to Food (formerly EAFUS) (2/2019), Europe, Canada; pharmaceutical. Source: EPA CPDat.

Is 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one used in cosmetics?

Yes, 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one is also indexed as a cosmetic ingredient under the name Phloretin Ingredient Analysis. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one used outside industrial chemicals?

3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one also appears in cosmetics, pharmaceutical, cannabis databases.