Ethyl-N2-dodecanoyl-L-argininate hydrochloride is classified GHS Danger (H318, H400) in the chemicals database but is restricted in EU cosmetics at max 0.4% (preservative); 0.8% (soap/shampoo/deodorant); 0.15% (mouthwash).
Australian industrial chemicals inventory status and applicable conditions.
SOURCEAICIS inventory1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. These obligations are: 1. A person introducing this chemical must tell us in writing within 28 calendar days if any of the following circumstances have occurred in relation to their introduction (importation or manufacture): a. the chemical is imported for use in spray products b. the chemical is used in cosmetic and personal care products at a concentration > 0.4%, unless being used as an active ingredient c. the chemical is used as an active ingredient in cosmetic and personal care products at a concentration > 0.8% 2. A person who introduces this chemical must tell us in writing within 28 calendar days if they become aware of any of the following circumstances, namely, that since the assessment under the Industrial Chemicals (Notification and Assessment) Act 1989: a. the function or use of the chemical has changed, or is likely to change, significantly; b. the amount of the chemical being introduced has increased, or is likely to increase, significantly; c. in the case of a chemical not manufactured, or proposed to be manufactured, in Australia at the time of the assessment—it has begun to be manufactured in Australia; d. the method of manufacture of the chemical in Australia has changed, or is likely to change, in a way that may result in an increased risk of an adverse effect of the chemical on occupational health and safety, public health or the environment; e. additional information has become available to the person as to an adverse effect of the chemical on occupational health and safety, public health or the environment.
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCEEU SCCS5 opinions
Opinion
Date
Conclusion
Max Conc.
Concerns
SCCS/1543/14
25 March 2015
safe with restrictions
Oral products (toothpaste) 0.15%; cosmetic products generally at previously established limits
Antimicrobial preservative; oral exposure concerns; previous opinion confirmed with addendum
SCCS/1519/13
12 December 2013
safe with restrictions
0.15% in toothpaste / oral products
Antimicrobial; confirmed safe in oral products at 0.15%
SCCS/1441/11
21 June 2011
Safe with restrictions — safe in mouthwashes at 0.15%; not established safe in toothpaste
Mouthwashes: 0.15%
Mucosal irritation (oral); chronic local toxicity concern in oral mucosa; safety in toothpaste could not be assessed due to absence of human data
SCCP/1132/08
15 April 2008
Safe with restrictions — safe at 0.4% as preservative (excluding lips, oral hygiene, sprays); safe at 0.8% in soap/anti-dandruff shampoos/deodorants
0.4% as preservative in most cosmetics; 0.8% in soap, anti-dandruff shampoos, and non-spray deodorants
Mucosal irritation (oral and lip mucosa); acute inhalation toxicity concern (spray exclusion); NOAEL from chronic rat study 271 mg/kg bw/day
SCCP/0836/04
15 March 2005
Insufficient data — mucosal irritation concern; additional data required before safety can be determined
N/A (assessment not complete)
Mucosal irritation; additional data required: clarification on purity/composition/impurities; acute inhalation toxicity study needed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
What is the GHS hazard classification for Ethyl-N2-dodecanoyl-L-argininate hydrochloride?
Ethyl-N2-dodecanoyl-L-argininate hydrochloride (CAS 60372-77-2) is classified under EU CLP Annex VI as Eye Dam. 1; Aquatic Acute 1 with signal word Danger. Hazard statements: H318; H400. Source: EU CLP Annex VI (ECHA).
What is the NOAEL for Ethyl-N2-dodecanoyl-L-argininate hydrochloride?
Ethyl-N2-dodecanoyl-L-argininate hydrochloride has 100 NOAEL studies in the database. The lowest reported value is 0.0897 mg/kg bw/d via oral in human. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.
What regulatory lists include Ethyl-N2-dodecanoyl-L-argininate hydrochloride?
Ethyl-N2-dodecanoyl-L-argininate hydrochloride appears on 3 regulatory/inventory lists including Europe; Personal care; restricted, Europe; Personal care, SCIL (9/2019). Source: EPA CPDat.
Is Ethyl-N2-dodecanoyl-L-argininate hydrochloride used in cosmetics?
Yes, Ethyl-N2-dodecanoyl-L-argininate hydrochloride is also indexed as a cosmetic ingredient under the name Ethyl Lauroyl Arginate HCl. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ethyl-N2-dodecanoyl-L-argininate hydrochloride come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Ethyl-N2-dodecanoyl-L-argininate hydrochloride have different safety status in cosmetics vs industrial chemicals?
Ethyl-N2-dodecanoyl-L-argininate hydrochloride is classified GHS Danger (H318, H400) in the chemicals database but is restricted in EU cosmetics at max 0.4% (preservative); 0.8% (soap/shampoo/deodorant); 0.15% (mouthwash).
Is Ethyl-N2-dodecanoyl-L-argininate hydrochloride used outside industrial chemicals?
Ethyl-N2-dodecanoyl-L-argininate hydrochloride also appears in cosmetics, food safety, cannabis databases.