Danger GHS05GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

Ethyl-N2-dodecanoyl-L-argininate hydrochloride

Also known as: Ethyl lauroyl arginate hydrochloride, Nα-Lauroyl-L-arginine-ethyl ester hydrochloride, Aminat G, Ethyl-Nα-lauroyl-L-arginate hydrochloride, Mirenat CF (+11 more)

CAS 60372-77-2

Ethyl-N2-dodecanoyl-L-argininate hydrochloride (CAS 60372-77-2) is a chemical substance with GHS signal word Danger; key hazard signal: H318; H400. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for Ethyl Lauroyl Arginate HCl →

SOURCE noael studies public
NOAEL studies
100
SOURCE chemical inventory jurisdictions
Regulatory lists
3
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 22 fields
Name
Ethyl-N2-dodecanoyl-L-argininate hydrochloride
CAS Number
60372-77-2
DTXSID
DTXSID40209136
Molecular Formula
C20H40N4O3.ClH
InChI Key
CUBZMGWLVMQKNE-LMOVPXPDSA-N
Monoisotopic Mass
420.286719
Synonyms
Ethyl lauroyl arginate hydrochlorideNα-Lauroyl-L-arginine-ethyl ester hydrochlorideAminat GEthyl-Nα-lauroyl-L-arginate hydrochlorideMirenat CFMirenat-Nethyl N2-dodecanoyl-L-argininate hydrochlorideL.A.E.Ethyl (2S)-5-carbamimidamido-2-(dodecanoylamino)pentanoate hydrochloride (1:1)L-Ornithine, N5-(diaminomethylene)-N2-(1-oxododecyl)-, ethyl ester, hydrochloride (1:1)UNII-XPD6ZY79TBEINECS 434-630-6

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Eye Dam. 1; Aquatic Acute 1H318; H400GHS05; GHS09Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 9 records
PreservativeSoftener and conditionerAntioxidant

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng
Europe; Personal careEuropean CommissionCosIng
SCIL (9/2019)USEPASafer Chemical Ingredients List

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
=0.0897mg/kg bw/d-oralhumanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
0.4%-oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
0.442mg/kg bw/day-oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
0.442mg/kg bw/day-oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
6--oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
6--oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
6--oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
6--oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
6--oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
26--oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
28----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
31--oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
31----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
31----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
55--oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
56mg/kg bw/day-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
56mg/kg bw/day-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
69.1%--rabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
69.1%--rabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
69.1%--rabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
69.1%--rabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
95--dermal-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
106mg/kg bw/day--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
106mg/kg bw/day--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
173---rabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
173---rabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
173---rabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
183--oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
183--oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
271mg/kg bw/day-oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
271mg/kg bw/day---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
271mg/kg bw/day---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
271mg/kg bw/day---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
271--oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
271mg/kg bw/day-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
271mg/kg bw/day-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
346--oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
346--oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=0.5mg/kg bw/dayADI-ConsumersEFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=0.5mg/kg bw/dayADI-ConsumersEFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
<=4mg/kgADIoralHumanToxValDB_WHO_JECFA_ADI
=21.652mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
XPD6ZY79TBUNIIFDA UNII substance identifier--openFDA substances
XPD6ZY79TBUNIIFDA UNII substance identifier--openFDA substances
XPD6ZY79TBUNIIFDA UNII substance identifier--openFDA substances
XPD6ZY79TBUNIIFDA UNII substance identifier--openFDA substances
=1000mg/kg bw/dayLELoralRabbitToxValDB_ECHA_IUCLID
=1270mg/kg bw/dayLELoralRatToxValDB_ECHA_IUCLID
=1330mg/kg bw/dayLELoralRatToxValDB_ECHA_IUCLID
=2000mg/kg bw/dayLELoralRatToxValDB_ECHA_IUCLID

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registeredethyl N2-dodecanoyl-l-argininate hydrochloride434-630-6ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. These obligations are: 1. A person introducing this chemical must tell us in writing within 28 calendar days if any of the following circumstances have occurred in relation to their introduction (importation or manufacture): a. the chemical is imported for use in spray products b. the chemical is used in cosmetic and personal care products at a concentration > 0.4%, unless being used as an active ingredient c. the chemical is used as an active ingredient in cosmetic and personal care products at a concentration > 0.8% 2. A person who introduces this chemical must tell us in writing within 28 calendar days if they become aware of any of the following circumstances, namely, that since the assessment under the Industrial Chemicals (Notification and Assessment) Act 1989: a. the function or use of the chemical has changed, or is likely to change, significantly; b. the amount of the chemical being introduced has increased, or is likely to increase, significantly; c. in the case of a chemical not manufactured, or proposed to be manufactured, in Australia at the time of the assessment—it has begun to be manufactured in Australia; d. the method of manufacture of the chemical in Australia has changed, or is likely to change, in a way that may result in an increased risk of an adverse effect of the chemical on occupational health and safety, public health or the environment; e. additional information has become available to the person as to an adverse effect of the chemical on occupational health and safety, public health or the environment.

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 5 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1543/1425 March 2015safe with restrictionsOral products (toothpaste) 0.15%; cosmetic products generally at previously established limitsAntimicrobial preservative; oral exposure concerns; previous opinion confirmed with addendum
SCCS/1519/1312 December 2013safe with restrictions0.15% in toothpaste / oral productsAntimicrobial; confirmed safe in oral products at 0.15%
SCCS/1441/1121 June 2011Safe with restrictions — safe in mouthwashes at 0.15%; not established safe in toothpasteMouthwashes: 0.15%Mucosal irritation (oral); chronic local toxicity concern in oral mucosa; safety in toothpaste could not be assessed due to absence of human data
SCCP/1132/0815 April 2008Safe with restrictions — safe at 0.4% as preservative (excluding lips, oral hygiene, sprays); safe at 0.8% in soap/anti-dandruff shampoos/deodorants0.4% as preservative in most cosmetics; 0.8% in soap, anti-dandruff shampoos, and non-spray deodorantsMucosal irritation (oral and lip mucosa); acute inhalation toxicity concern (spray exclusion); NOAEL from chronic rat study 271 mg/kg bw/day
SCCP/0836/0415 March 2005Insufficient data — mucosal irritation concern; additional data required before safety can be determinedN/A (assessment not complete)Mucosal irritation; additional data required: clarification on purity/composition/impurities; acute inhalation toxicity study needed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
0.4% (preservative); 0.8% (soap/shampoo/deodorant); 0.15% (mouthwash)
Category
preservative
View full cosmetic safety profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 2 records

E243 — ADI: 0-4 mg/kg bw mg/kg bw | FDA GRAS: FDA has no questions

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Ethyl-N2-dodecanoyl-L-argininate hydrochloride?

Ethyl-N2-dodecanoyl-L-argininate hydrochloride (CAS 60372-77-2) is classified under EU CLP Annex VI as Eye Dam. 1; Aquatic Acute 1 with signal word Danger. Hazard statements: H318; H400. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Ethyl-N2-dodecanoyl-L-argininate hydrochloride?

Ethyl-N2-dodecanoyl-L-argininate hydrochloride has 100 NOAEL studies in the database. The lowest reported value is 0.0897 mg/kg bw/d via oral in human. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.

What regulatory lists include Ethyl-N2-dodecanoyl-L-argininate hydrochloride?

Ethyl-N2-dodecanoyl-L-argininate hydrochloride appears on 3 regulatory/inventory lists including Europe; Personal care; restricted, Europe; Personal care, SCIL (9/2019). Source: EPA CPDat.

Is Ethyl-N2-dodecanoyl-L-argininate hydrochloride used in cosmetics?

Yes, Ethyl-N2-dodecanoyl-L-argininate hydrochloride is also indexed as a cosmetic ingredient under the name Ethyl Lauroyl Arginate HCl. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Ethyl-N2-dodecanoyl-L-argininate hydrochloride come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Ethyl-N2-dodecanoyl-L-argininate hydrochloride have different safety status in cosmetics vs industrial chemicals?

Ethyl-N2-dodecanoyl-L-argininate hydrochloride is classified GHS Danger (H318, H400) in the chemicals database but is restricted in EU cosmetics at max 0.4% (preservative); 0.8% (soap/shampoo/deodorant); 0.15% (mouthwash).

Is Ethyl-N2-dodecanoyl-L-argininate hydrochloride used outside industrial chemicals?

Ethyl-N2-dodecanoyl-L-argininate hydrochloride also appears in cosmetics, food safety, cannabis databases.