Is Ethyl Lauroyl Arginate HCl safe in cosmetics?
Ethyl Lauroyl Arginate HCl has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Ethyl Lauroyl Arginate HCl
Also known as: Ethyl lauroyl arginate hydrochloride, Nα-Lauroyl-L-arginine-ethyl ester hydrochloride, Aminat G, Ethyl-Nα-lauroyl-L-arginate hydrochloride, Mirenat CF (+10 more)
INCI: ETHYL LAUROYL ARGINATE HCL
Ethyl Lauroyl Arginate HCl (CAS 60372-77-2) is a cosmetic preservative functioning as Preservative, Cationic Surfactant, Hair/Skin Conditioning. NOAEL 271 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 0.4% (preservative); 0.8% (soap/shampoo/deodorant); 0.15% (mouthwash). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 60372-77-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Ethyl Lauroyl Arginate HCl is classified GHS Danger (H318, H400, H412, H315) in the chemicals database but is restricted in EU cosmetics at max 0.4% (preservative); 0.8% (soap/shampoo/deodorant); 0.15% (mouthwash).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Preservative, Cationic Surfactant, Hair/Skin Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
ethyl (2S)-5-(diaminomethylideneamino)-2-(dodecanoylamino)pentanoate;hydrochloride
InChIKey
CUBZMGWLVMQKNE-LMOVPXPDSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
0.4% (preservative); 0.8% (soap/shampoo/deodorant); 0.15% (mouthwash)
US US Status
permitted
US Notes
GRAS for food (200 ppm). No specific cosmetic restrictions. No dedicated CIR report.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethyl Lauroyl Arginate HCl.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Ethyl Lauroyl Arginate HCl. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.0897 mg/kg bw/d | oral | human | NOAEL study | SCCS_vision_codex |
| NOAEL | =0.0897 mg/kg bw/d | oral | human | NOAEL study | SCCS_vision_codex |
| NOAEL | =0.0897 mg/kg bw/d | oral | human | NOAEL study | SCCS_vision_codex |
| NOAEL | =0.0897 mg/kg bw/d | oral | human | NOAEL study | SCCS_vision_codex |
| NOAEL | =0.442 mg/kg bw/day | oral | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =0.442 mg/kg bw/day | oral | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =0.442 mg/kg bw/day | oral | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =0.442 mg/kg bw/day | oral | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =1.19 mg/kg/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =1.19 mg/kg/d | oral | rat | dermal absorption | SCCS_vision_codex |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Ethyl Lauroyl Arginate HCl across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
CorrosiveEnvironmental Hazard
Hazard Class and Category
Eye Dam. 1; Aquatic Acute 1
Hazard Statements
- H318 Causes serious eye damage
- H400 Very toxic to aquatic life
Inserted via ATP: ATP01
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex V — Permitted Preservatives
Product type: (a) Mouthwashes
(b) Other products
Max: (a) 0,15 %
(b) 0,4 %
(a) Not to be used for children under 10 years of age
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
KR Korea MFDS Annex 2 (Restricted)
Category: Preservative. Max: 0.4%. Lips & aerosol prohibited
SA Saudi SFDA (III - Restricted)
Product type: (a) soap (b) anti- dandruff shampoos (c) deodorants, not in form of spray. Max: 0,8 %.
BRIN Brazil/India Cosmetics
Brazil: Permitted Preservative · max a) 0,15% em enxaguatórios bucais. b) 0,4% em outros produtos.
India: Restricted · max 0,8 %
India: Permitted Preservative · max (a) 0,15 % (b) 0,4 %
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_preservative | 0.4 | All cosmetics |
| BR | permitted_preservative | 0.15 (mouthwash) / 0.4 (other) | a) Mouthwashes: 0.15%; b) Other products: 0.4%; not in children's products; not in oral products/lips (except mouthwash); not in sprays |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (3 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 5.24% | - | - | SCCP/0837/04 |
| measured_sccs_opinion | 0.4% | - | - | SCCP/1106/07 |
| measured_sccs_opinion | 3.0% | - | - | SCCS/1519/13 |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Preservative
Softener and conditioner
Regulatory List Membership (3)
EU Regulated in Personal Care
EPA Safer Chemical Ingredients List (SCIL)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Ethyl Lauroyl Arginate HCl.
Regulatory Flags
EU_RESTRICTED
epa_safer_alternative
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Ethyl Lauroyl Arginate HCl by CAS number or substance name.
Studies
84
Lowest NOAEL
0.0897
Highest NOAEL
2600
Units vary across source rows: mg/kg bw/d, mg/kg bw/day, mg/kg/d
SCCS_vision_codex
ToxValDB_ECHA_IUCLID
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 5.24% | SCCS opinion extraction | - |
| 0.4% | SCCS opinion extraction | - |
| 3.0% | SCCS opinion extraction | - |
Known Synonyms
Ethyl lauroyl arginate hydrochloride
Nα-Lauroyl-L-arginine-ethyl ester hydrochloride
Aminat G
Ethyl-Nα-lauroyl-L-arginate hydrochloride
Mirenat CF
Mirenat-N
ethyl N2-dodecanoyl-L-argininate hydrochloride
L.A.E.
Ethyl (2S)-5-carbamimidamido-2-(dodecanoylamino)pentanoate hydrochloride (1:1)
L-Ornithine, N5-(diaminomethylene)-N2-(1-oxododecyl)-, ethyl ester, hydrochloride (1:1)
UNII-XPD6ZY79TB
EINECS 434-630-6
L-Arginine, N2-(1-oxododecyl)-, ethyl ester, hydrochloride (1:1)
L-Arginine, N2-(1-oxododecyl)-, ethyl ester, monohydrochloride
Cytoguard LA
Chemical Function
Preservative
Softener and conditioner
Antioxidant
Regulatory Lists
Europe; Personal care; restricted
Europe; Personal care
SCIL (9/2019)
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. These obligations are: 1. A person introducing this chemical must tell us in writing within 28 calendar days if any of the following circumstances have occurred in relation to their introduction (importation or manufacture): a. the chemical is imported for use in spray products b....
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives + fda_gras_enriched
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Ethyl lauroyl arginate
E Number
E243
ADI
0-4 mg/kg bw mg/kg bw
FDA GRAS
FDA has no questions
GRN
164
Food Category
preservative
Antimicrobial ingredient added directly to food, including meat and poultry
View full food safety profile →Frequently Asked Questions
Is Ethyl Lauroyl Arginate HCl allowed in the EU?
Ethyl Lauroyl Arginate HCl EU regulatory status: restricted. Maximum allowed concentration: 0.4% (preservative); 0.8% (soap/shampoo/deodorant); 0.15% (mouthwash). This is based on EU Regulation 1223/2009 and its amendments.
What does Ethyl Lauroyl Arginate HCl do in cosmetics?
Ethyl Lauroyl Arginate HCl functions as: Preservative, Cationic Surfactant, Hair/Skin Conditioning. It is classified as a Preservative in our database. CAS number: 60372-77-2.
What is the NOAEL for Ethyl Lauroyl Arginate HCl?
The NOAEL (No Observed Adverse Effect Level) for Ethyl Lauroyl Arginate HCl is =0.0897 mg/kg bw/d based on a NOAEL study study via oral route in human. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Is Ethyl Lauroyl Arginate HCl used outside cosmetics?
Ethyl Lauroyl Arginate HCl also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Ethyl Lauroyl Arginate HCl have different safety status in cosmetics vs industrial chemicals?
Ethyl Lauroyl Arginate HCl is classified GHS Danger (H318, H400, H412, H315) in the chemicals database but is restricted in EU cosmetics at max 0.4% (preservative); 0.8% (soap/shampoo/deodorant); 0.15% (mouthwash).
Compliance Tools
Check Ethyl Lauroyl Arginate HCl compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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