Good Preservative NOAEL Data

Ethyl Lauroyl Arginate HCl

INCI: ETHYL LAUROYL ARGINATE HCL

CAS Number
60372-77-2
Function
Preservative, Cationic Surfactant, Hair/Skin Conditioning
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
EU Max Conc. 0.4% (preservative); 0.8% (soap/shampoo/deodorant); 0.15% (mouthwash)
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes GRAS for food (200 ppm). No specific cosmetic restrictions. No dedicated CIR report.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Ethyl Lauroyl Arginate HCl. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 2000 ppm oral rat Chronic COSMOS_DB

Expert Verdict

Safe at 0.4% preservative (all except lip/oral/spray); 0.8% active (soap/shampoo/deodorant, non-spray). Excluded from lip, most oral, and spray products. Cationic - incompatible with anionic surfactants.

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Concern Level: Low

Regulatory Flags

EU_RESTRICTED epa_safer_alternative eu_cosing_listed

Frequently Asked Questions

Is Ethyl Lauroyl Arginate HCl safe in cosmetics?

Safe at 0.4% preservative (all except lip/oral/spray); 0.8% active (soap/shampoo/deodorant, non-spray). Excluded from lip, most oral, and spray products. Cationic - incompatible with anionic surfactants. The EU classifies Ethyl Lauroyl Arginate HCl as "restricted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is Ethyl Lauroyl Arginate HCl allowed in the EU?

Ethyl Lauroyl Arginate HCl EU regulatory status: restricted. Maximum allowed concentration: 0.4% (preservative); 0.8% (soap/shampoo/deodorant); 0.15% (mouthwash). This is based on EU Regulation 1223/2009 and its amendments.

What does Ethyl Lauroyl Arginate HCl do in cosmetics?

Ethyl Lauroyl Arginate HCl functions as: Preservative, Cationic Surfactant, Hair/Skin Conditioning. It is classified as a Preservative in our database. CAS number: 60372-77-2.

What is the Margin of Safety for Ethyl Lauroyl Arginate HCl?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Ethyl Lauroyl Arginate HCl?

The NOAEL (No Observed Adverse Effect Level) for Ethyl Lauroyl Arginate HCl is 2000 ppm based on a Chronic study via oral route in rat. Source: COSMOS_DB.

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