NOAEL Data REACH Registered Cosmetic Ingredient

2-Methyl-1,3-benzenediol

Also known as: 4-06-00-05877, BRN 2042177, EINECS 210-155-8, UNII-32W7044A3T

CAS 608-25-3

2-Methyl-1,3-benzenediol (CAS 608-25-3) is a chemical substance. Key regulatory status: REACH registered, 16 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for 2-Methylresorcinol ⭐ (Most extensively assessed) →

Cross-Vertical Regulatory Divergence

2-Methyl-1,3-benzenediol is prohibited in EU cosmetics at max 1.8% but has active industrial GHS classifications (H301, H315, H317, H318, H319, H335, H400, H410).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 9 fields

Name

2-Methyl-1,3-benzenediol

CAS Number

608-25-3

Molecular Formula

C7H8O2

InChI Key

ZTMADXFOCUXMJE-UHFFFAOYSA-N

Monoisotopic Mass

124.052429

Synonyms

4-06-00-05877BRN 2042177EINECS 210-155-8UNII-32W7044A3T

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 16 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring - hair color - permanent	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring - hair color - permanent	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring - hair color - professional	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring - hair color - professional	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring - hair color - professional	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring - hair color - professional	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 26 of 26 studies

Value	Unit	Endpoint	Route	Species	Source
100	mg/kg bw	-	-	-	Regulatory source
=4.93	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
32W7044A3T	UNII	FDA UNII substance identifier	-	-	openFDA substances
=200	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
100	mg/kg bw/day	LOAEL	oral	rat	COSMOS DB
=0.024	mg/kg	NOAEL	dermal	human	SCCS Opinion
=0.024	mg/kg bw	NOAEL	dermal	human	SCCS Opinion
=0.14	mg/kg bw	NOAEL	dermal	human	SCCS Opinion
=100	mg/kg bw/day	NOAEL	oral	Rat	ECHA
=100	mg/kg bw	NOAEL	-	-	SCCS Opinion
=100	mg/kg	NOAEL	dermal	human	SCCS Opinion
=400	mg/kg bw/day	NOAEL	oral	Rat	ECHA
=400	mg/kg bw/day	NOAEL	-	-	SCCS Opinion
=900	mg/kg bw	NOAEL	oral	rat	SCCS Opinion
400	mg/kg bw/day	dermal absorption	dermal	mouse	Regulatory source
900	mg/kg bw	developmental toxicity	oral	rat	Regulatory source
100	mg/kg bw	genotoxicity	-	-	Regulatory source
100	mg/kg bw	irritation	-	rabbit	Regulatory source
100	mg/kg bw	irritation	-	mouse	Regulatory source
400	mg/kg bw/day	irritation	-	mouse	Regulatory source
=0.024	mg/kg	repeated dose toxicity	dermal	human	Regulatory source
=0.024	mg/kg bw	repeated dose toxicity	dermal	human	Regulatory source
=0.14	mg/kg bw	repeated dose toxicity	dermal	human	Regulatory source
=100	mg/kg	repeated dose toxicity	dermal	human	Regulatory source
=100	mg/kg bw	repeated dose toxicity	dermal	human	Regulatory source
400	mg/kg bw/day	reproductive toxicity	-	-	Regulatory source

Showing 26 of 26 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	2-methylresorcinol	210-155-8	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 2 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCP/1186/08	16 December 2008	safe	1.8%	sensitisation potential; moderate
SCCP/1206/08	2008-12-16	Based on the information provided, the SCCP is of the opinion that the use of 2-methylresorcinol itself as an ingredient in non-oxidative and oxidative hair dye formulations at a maximum on-head concentration of 1.8% does not pose a risk to the health of the consumer apart from its skin sensitising potential.	1.8% on-head	Skin sensitising potential. Genotoxicity/mutagenicity of finished hair dye formulations should be studied. Function of 2-methylresorcinol in non-oxidative hair dye formulations is unclear.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

1.8%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL2332773

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 2-Methyl-1,3-benzenediol?

2-Methyl-1,3-benzenediol has 26 NOAEL studies in the database. The lowest reported value is 4.93 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.

What regulatory lists include 2-Methyl-1,3-benzenediol?

2-Methyl-1,3-benzenediol appears on 5 regulatory/inventory lists including Europe; Personal care; restricted, Europe; Personal care - hair coloring, detected; Europe; Personal care - hair coloring - hair color - permanent, and 2 more. Source: EPA CPDat.

Is 2-Methyl-1,3-benzenediol used in cosmetics?

Yes, 2-Methyl-1,3-benzenediol is also indexed as a cosmetic ingredient under the name 2-Methylresorcinol ⭐ (Most extensively assessed). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Methyl-1,3-benzenediol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Methyl-1,3-benzenediol have different safety status in cosmetics vs industrial chemicals?

2-Methyl-1,3-benzenediol is prohibited in EU cosmetics at max 1.8% but has active industrial GHS classifications (H301, H315, H317, H318, H319, H335, H400, H410).

Is 2-Methyl-1,3-benzenediol used outside industrial chemicals?

2-Methyl-1,3-benzenediol also appears in cosmetics, pharmaceutical databases.