NOAEL Data REACH Registered Cosmetic Ingredient

Tert-Butyl perbenzoate

Also known as: Benzenecarboperoxoic acid, 1,1-dimethylethyl ester, BRN 1342734, t-Butyl perbenzoate, tert-Butyl peroxy benzoate, t-Butyl peroxy benzoate (+6 more)

CAS 614-45-9

Tert-Butyl perbenzoate (CAS 614-45-9) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for t-Butyl Benzoyl Peroxide →

Cross-Vertical Regulatory Divergence

Tert-Butyl perbenzoate is classified GHS Danger (H242, H315, H317, H332, H400, H412, H227, H320) in the chemicals database but is restricted in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 16 fields

Name

Tert-Butyl perbenzoate

CAS Number

614-45-9

Molecular Formula

C11H14O3

InChI Key

GJBRNHKUVLOCEB-UHFFFAOYSA-N

Monoisotopic Mass

194.094294

Synonyms

Benzenecarboperoxoic acid, 1,1-dimethylethyl esterBRN 1342734t-Butyl perbenzoatetert-Butyl peroxy benzoatet-Butyl peroxy benzoateEINECS 210-382-2Perbenzoic acid, tert-butyl esterPerbenzoate de butyle tertiaireterc.Butylester kyseliny peroxybenzooveterc.ButylperbenzoanUNII-54E39145KT

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 28 records

UV stabilizerBinderCatalystHardenerChemical reaction regulator

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records

List	Keyword	Source
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
drinking_water; Europe; manufacturing; plastic_additive	Belgaqua	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 32 of 32 studies

Value	Unit	Endpoint	Route	Species	Source
=24.7	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
54E39145KT	UNII	FDA UNII substance identifier	-	-	openFDA substances
>0.26	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
=1012	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=2000	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=60	mg/kg bw/day	LEL	oral	Rat	ToxValDB ToxRefDB
=60	mg/kg bw/day	LEL	oral	rat (fischer; Fischer 344)	EPA ToxRefDB v3
=278	mg/kg bw/day	LEL	oral	Mouse	ToxValDB ToxRefDB
=278	mg/kg bw/day	LEL	oral	mouse (b6c3f1; B6C3F1)	EPA ToxRefDB v3
=300	mg/kg bw/day	LEL	oral	Rabbit	ToxValDB EPA TSCA 8e
=400	mg/kg bw/day	LEL	oral	Rabbit	ToxValDB EPA TSCA 8e
=250	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB ToxRefDB
=250	mg/kg bw/day	LOAEL	oral	rat (fischer; Fischer 344)	EPA ToxRefDB v3
0	unitless	Model Score	-	-	NTP ICE endocrine
>0	mg/kg bw/day	NEL	oral	rat (fischer; Fischer 344)	EPA ToxRefDB v3
=30	mg/kg bw/day	NEL	oral	rat (fischer; Fischer 344)	EPA ToxRefDB v3
=140	mg/kg bw/day	NEL	oral	Mouse	ToxValDB ToxRefDB
=140	mg/kg bw/day	NEL	oral	mouse (b6c3f1; B6C3F1)	EPA ToxRefDB v3
=3178	mg/m3	NOAEC	inhalation	Rat	ECHA
=6.355e+4	mg/m3	NOAEC	inhalation	Rat	ECHA
~30	mg/kg bw/day	NOAEL	oral	Rat	ECHA
=125	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB ToxRefDB
=125	mg/kg bw/day	NOAEL	oral	rat (fischer; Fischer 344)	EPA ToxRefDB v3
=160	mg/kg bw/day	NOAEL	oral	Rat	ECHA
>200	mg/kg bw/day	NOAEL	oral	Rabbit	ECHA
=250	mg/kg bw/day	NOAEL	oral	Rabbit	ECHA
<=300	mg/kg bw/day	NOAEL	oral	Rabbit	ECHA
=400	mg/kg bw/day	NOAEL	oral	Rat	ECHA
=100	mg/kg bw/day	NOEL	oral	Rat	ECHA
=300	mg/kg bw/day	NOEL	oral	Rat	ECHA
=750	mg/kg bw/day	NOEL	oral	Rat	ECHA
=1000	mg/kg bw/day	NOEL	oral	Rat	ECHA

Showing 32 of 32 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	tert-butyl perbenzoate	210-382-2	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL1328092

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for Tert-Butyl perbenzoate?

Tert-Butyl perbenzoate has 32 NOAEL studies in the database. The lowest reported value is 24.7 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.

What regulatory lists include Tert-Butyl perbenzoate?

Tert-Butyl perbenzoate appears on 3 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Indirect additives food contact (10/2018), drinking_water; Europe; manufacturing; plastic_additive. Source: EPA CPDat.

Is Tert-Butyl perbenzoate used in cosmetics?

Yes, Tert-Butyl perbenzoate is also indexed as a cosmetic ingredient under the name t-Butyl Benzoyl Peroxide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Tert-Butyl perbenzoate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Tert-Butyl perbenzoate have different safety status in cosmetics vs industrial chemicals?

Tert-Butyl perbenzoate is classified GHS Danger (H242, H315, H317, H332, H400, H412, H227, H320) in the chemicals database but is restricted in EU cosmetics.

Is Tert-Butyl perbenzoate used outside industrial chemicals?

Tert-Butyl perbenzoate also appears in cosmetics, pharmaceutical databases.