Is t-Butyl Benzoyl Peroxide safe in cosmetics?
t-Butyl Benzoyl Peroxide has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
t-Butyl Benzoyl Peroxide
Also known as: Benzenecarboperoxoic acid, 1,1-dimethylethyl ester, BRN 1342734, t-Butyl perbenzoate, tert-Butyl peroxy benzoate, t-Butyl peroxy benzoate (+6 more)
INCI: T-BUTYL BENZOYL PEROXIDE
t-Butyl Benzoyl Peroxide (CAS 614-45-9) is a cosmetic cosmetic ingredient functioning as UV Absorber (per CosIng); organic peroxide with oxidizing properties. Reported NOAEL =160 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 614-45-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
t-Butyl Benzoyl Peroxide is classified GHS Danger (H242, H315, H317, H332, H400, H412, H227, H320) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
UV Absorber (per CosIng); organic peroxide with oxidizing properties
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
tert-butyl benzenecarboperoxoate
InChIKey
GJBRNHKUVLOCEB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Benzoyl peroxide is an FDA-approved OTC active for acne; t-butyl benzoyl peroxide is not separately monographed — would require separate evaluation
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for t-Butyl Benzoyl Peroxide.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for t-Butyl Benzoyl Peroxide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =160 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =250 mg/kg bw/day | oral | Rabbit | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =400 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
Skin: Not an irritant or sensitizer. Eye: Slight irritation. /From table/ | A skin and eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Binder
Catalyst
Chemical reaction regulator
Hardener
UV stabilizer
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for t-Butyl Benzoyl Peroxide.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to t-Butyl Benzoyl Peroxide by CAS number or substance name.
Studies
3
Lowest NOAEL
160 mg/kg bw/day
Highest NOAEL
400 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Benzenecarboperoxoic acid, 1,1-dimethylethyl ester
BRN 1342734
t-Butyl perbenzoate
tert-Butyl peroxy benzoate
t-Butyl peroxy benzoate
EINECS 210-382-2
Perbenzoic acid, tert-butyl ester
Perbenzoate de butyle tertiaire
terc.Butylester kyseliny peroxybenzoove
terc.Butylperbenzoan
UNII-54E39145KT
Chemical Function
UV stabilizer
Binder
Catalyst
Hardener
Chemical reaction regulator
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Indirect additives food contact (10/2018)
drinking_water; Europe; manufacturing; plastic_additive
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1328092
Frequently Asked Questions
Is t-Butyl Benzoyl Peroxide allowed in the EU?
t-Butyl Benzoyl Peroxide EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does t-Butyl Benzoyl Peroxide do in cosmetics?
t-Butyl Benzoyl Peroxide functions as: UV Absorber (per CosIng); organic peroxide with oxidizing properties. It is classified as a cosmetic ingredient in our database. CAS number: 614-45-9.
What is the NOAEL for t-Butyl Benzoyl Peroxide?
The NOAEL (No Observed Adverse Effect Level) for t-Butyl Benzoyl Peroxide is =160 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is t-Butyl Benzoyl Peroxide used outside cosmetics?
t-Butyl Benzoyl Peroxide also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does t-Butyl Benzoyl Peroxide have different safety status in cosmetics vs industrial chemicals?
t-Butyl Benzoyl Peroxide is classified GHS Danger (H242, H315, H317, H332, H400, H412, H227, H320) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check t-Butyl Benzoyl Peroxide compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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