What is the NOAEL for 2-Chloro-1,4-diaminobenzene?
2-Chloro-1,4-diaminobenzene has 19 NOAEL studies in the database. The lowest reported value is 3.29 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Chloro-1,4-diaminobenzene
Also known as: 4-13-00-00221, BRN 2802557, 2-Chloro-(1,4-phenylenediamine), 1,4-Diamino-2-chlorobenzene, EINECS 210-441-2 (+11 more)
CAS 615-66-7
2-Chloro-1,4-diaminobenzene (CAS 615-66-7) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
View cosmetic safety profile for 2-Chloro-P-Phenylenediamine →
Cross-Vertical Regulatory Divergence
2-Chloro-1,4-diaminobenzene is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H332, H315, H319, H317).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
19
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
22 fields
Name
2-Chloro-1,4-diaminobenzene
CAS Number
615-66-7
DTXSID
DTXSID3043944
Molecular Formula
C6H7ClN2
InChI Key
MGLZGLAFFOMWPB-UHFFFAOYSA-N
Monoisotopic Mass
142.029776
Synonyms
4-13-00-00221BRN 28025572-Chloro-(1,4-phenylenediamine)1,4-Diamino-2-chlorobenzeneEINECS 210-441-2Ursol Brown O2-Chlor-p-fenylendiamin3-Chloro-p-fenylendiamin3-Chlor-p-fenylendiaminUNII-W949BCC82R2-Chloro-1,4-benzenediamine2-Chloro-4-phenylenediamine
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 19 of 19 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =3.29 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| W949BCC82R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| W949BCC82R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| W949BCC82R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| W949BCC82R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =100 | mg/kg bw/d | NOAEL | - | rat | SCCS_vision_codex |
| =100 | mg/kg bw/d | NOAEL | - | rat | SCCS_vision_codex |
| =100 | mg/kg bw/d | NOAEL | - | rat | SCCS_vision_codex |
| =100 | mg/kg bw/d | NOAEL | - | rat | SCCS_vision_codex |
| =200 | mg/kg bw/d | NOAEL | - | rat | SCCS_vision_codex |
| =200 | mg/kg bw/d | NOAEL | - | rat | SCCS_vision_codex |
| =200 | mg/kg bw/d | NOAEL | - | rat | SCCS_vision_codex |
| =200 | mg/kg bw/d | NOAEL | - | rat | SCCS_vision_codex |
| =63 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECOTOX |
| =189 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECOTOX |
| 100 | mg/kg bw/d | developmental toxicity | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 200 | mg/kg bw/d | developmental toxicity | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 100 | mg/kg bw/d | repeated dose toxicity | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 200 | mg/kg bw/d | repeated dose toxicity | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
Showing 19 of 19 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-chloro-p-phenylenediamine | 210-441-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1510/13 | 19 September 2013 | not safe | - | genotoxicity potential; strong sensitiser |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1619318
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 2-Chloro-1,4-diaminobenzene?
2-Chloro-1,4-diaminobenzene appears on 1 regulatory/inventory list including banned; Europe; Personal care. Source: EPA CPDat.
Is 2-Chloro-1,4-diaminobenzene used in cosmetics?
Yes, 2-Chloro-1,4-diaminobenzene is also indexed as a cosmetic ingredient under the name 2-Chloro-P-Phenylenediamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Chloro-1,4-diaminobenzene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Chloro-1,4-diaminobenzene have different safety status in cosmetics vs industrial chemicals?
2-Chloro-1,4-diaminobenzene is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H332, H315, H319, H317).
Is 2-Chloro-1,4-diaminobenzene used outside industrial chemicals?
2-Chloro-1,4-diaminobenzene also appears in cosmetics, pharmaceutical databases.