Also known as: 4-13-00-00221, BRN 2802557, 2-Chloro-(1,4-phenylenediamine), 1,4-Diamino-2-chlorobenzene, EINECS 210-441-2 (+10 more)
INCI: 2-CHLORO-P-PHENYLENEDIAMINE
2-Chloro-P-Phenylenediamine (CAS 615-66-7) is a cosmetic cosmetic ingredient functioning as Hair dyeing (oxidative dye intermediate). NOAEL 63 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited; 1 safety opinion reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 615-66-7 →
2-Chloro-P-Phenylenediamine is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H332, H315, H319, H317).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Chloro-P-Phenylenediamine.
Calculate MoS for your specific formulation with the MoS Calculator.
8 study endpoints found for 2-Chloro-P-Phenylenediamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =100 mg/kg bw/d | - | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =100 mg/kg bw/d | - | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =100 mg/kg bw/d | - | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =100 mg/kg bw/d | - | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =200 mg/kg bw/d | - | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =200 mg/kg bw/d | - | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =200 mg/kg bw/d | - | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =200 mg/kg bw/d | - | rat | developmental toxicity | SCCS_vision_codex |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Pre-calculated NOAEL → SED → MoS audit trail for 2-Chloro-P-Phenylenediamine across SCCS product categories, with measured dermal absorption where available.
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | banned | - | - |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 100.0% | - | - | SCCS/1510/13 |
Expert safety assessment and concern-level summary for 2-Chloro-P-Phenylenediamine.
Public NOAEL study rows linked to 2-Chloro-P-Phenylenediamine by CAS number or substance name.
Units vary across source rows: mg/kg bw/d, mg/kg bw/day
| Absorption % | Method | Vehicle |
|---|---|---|
| 100.0% | SCCS PDF direct extraction | - |
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
2-Chloro-P-Phenylenediamine has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted. 8 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
2-Chloro-P-Phenylenediamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
2-Chloro-P-Phenylenediamine functions as: Hair dyeing (oxidative dye intermediate). It is classified as a cosmetic ingredient in our database. CAS number: 615-66-7.
The NOAEL (No Observed Adverse Effect Level) for 2-Chloro-P-Phenylenediamine is =100 mg/kg bw/d based on a developmental toxicity study via oral route in rat. A total of 8 study endpoints are available. Source: SCCS_vision_codex.
2-Chloro-P-Phenylenediamine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
2-Chloro-P-Phenylenediamine is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H332, H315, H319, H317).
Check 2-Chloro-P-Phenylenediamine compliance across multiple jurisdictions:
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 2-Chloro-P-Phenylenediamine in your formulation.