What is the NOAEL for 2,5-Furandione, 3-methyl-?
2,5-Furandione, 3-methyl- has 5 NOAEL studies in the database. The lowest reported value is 105NP7PMXX UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2,5-Furandione, 3-methyl-
Also known as: 5-17-11-00065, BRN 0001835, EINECS 210-459-0, Maleic anhydride, methyl-, Anhydrid kyseliny citrakonove (+1 more)
CAS 616-02-4
2,5-Furandione, 3-methyl- (CAS 616-02-4) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
Cross-Vertical Regulatory Divergence
2,5-Furandione, 3-methyl- is prohibited in EU cosmetics but has active industrial GHS classifications (H311, H314, H317, H318, H334, H335).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
2,5-Furandione, 3-methyl-
CAS Number
616-02-4
DTXSID
DTXSID8060660
Molecular Formula
C5H4O3
InChI Key
AYKYXWQEBUNJCN-UHFFFAOYSA-N
Monoisotopic Mass
112.016044
Synonyms
5-17-11-00065BRN 0001835EINECS 210-459-0Maleic anhydride, methyl-Anhydrid kyseliny citrakonoveUNII-105NP7PMXX
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
No specific technical function
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 105NP7PMXX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 105NP7PMXX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 105NP7PMXX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 105NP7PMXX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =2600 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Citraconic anhydride | 210-459-0 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL398893
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
Is 2,5-Furandione, 3-methyl- used in cosmetics?
Yes, 2,5-Furandione, 3-methyl- is also indexed as a cosmetic ingredient under the name Citraconic Anhydride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,5-Furandione, 3-methyl- come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 2,5-Furandione, 3-methyl- have different safety status in cosmetics vs industrial chemicals?
2,5-Furandione, 3-methyl- is prohibited in EU cosmetics but has active industrial GHS classifications (H311, H314, H317, H318, H334, H335).
Is 2,5-Furandione, 3-methyl- used outside industrial chemicals?
2,5-Furandione, 3-methyl- also appears in cosmetics, pharmaceutical databases.