Is Citraconic Anhydride safe in cosmetics?
Citraconic Anhydride has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
Poor
Cosmetic Ingredient
Citraconic Anhydride
Also known as: 5-17-11-00065, BRN 0001835, EINECS 210-459-0, Maleic anhydride, methyl-, Anhydrid kyseliny citrakonove (+1 more)
Citraconic Anhydride (CAS 616-02-4) is a cosmetic cosmetic ingredient functioning as No specific technical function. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 616-02-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Citraconic Anhydride is prohibited in EU cosmetics but has active industrial GHS classifications (H311, H314, H317, H318, H334, H335).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
No specific technical function
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
3-methylfuran-2,5-dione
InChIKey
AYKYXWQEBUNJCN-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
No CIR review; not commonly used as a finished cosmetic ingredient; TSCA listed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Citraconic Anhydride.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Expert Verdict
Expert safety assessment and concern-level summary for Citraconic Anhydride.
Regulatory Flags
potential-allergen
Known Synonyms
5-17-11-00065
BRN 0001835
EINECS 210-459-0
Maleic anhydride, methyl-
Anhydrid kyseliny citrakonove
UNII-105NP7PMXX
Chemical Function
No specific technical function
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL398893
Frequently Asked Questions
Is Citraconic Anhydride allowed in the EU?
Citraconic Anhydride EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Citraconic Anhydride do in cosmetics?
Citraconic Anhydride functions as: No specific technical function. It is classified as a cosmetic ingredient in our database. CAS number: 616-02-4.
Is Citraconic Anhydride used outside cosmetics?
Citraconic Anhydride also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Citraconic Anhydride have different safety status in cosmetics vs industrial chemicals?
Citraconic Anhydride is prohibited in EU cosmetics but has active industrial GHS classifications (H311, H314, H317, H318, H334, H335).
Compliance Tools
Check Citraconic Anhydride compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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