What is the NOAEL for N-Acetyl-L-cysteine?
N-Acetyl-L-cysteine has 8 NOAEL studies in the database. The lowest reported value is WYQ7N0BPYC UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
N-Acetyl-L-cysteine
Also known as: L-Cysteine, N-acetyl-, Cysteine, N-acetyl-, L-, (2R)-2Acetamido-3-sulfanylpropanoic acid, Acetadote, Asist (+14 more)
CAS 616-91-1
N-Acetyl-L-cysteine (CAS 616-91-1) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
N-Acetyl-L-cysteine
CAS Number
616-91-1
DTXSID
DTXSID5020021
Molecular Formula
C5H9NO3S
InChI Key
PWKSKIMOESPYIA-BYPYZUCNSA-N
Monoisotopic Mass
163.030314
Synonyms
L-Cysteine, N-acetyl-Cysteine, N-acetyl-, L-(2R)-2Acetamido-3-sulfanylpropanoic acidAcetadoteAsistBrunacBroncholysin (mucolytic)CysteplusExomucN-Acetyl-(R)-cysteineTixairTrom
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
AntioxidantSoftener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| WYQ7N0BPYC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| WYQ7N0BPYC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| WYQ7N0BPYC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| WYQ7N0BPYC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.17 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| =3000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =5050 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >6000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Acetylcysteine | 210-498-3 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ACETYLCYSTEINE
ChEMBL Phase
4
Adverse Events
3000
Bioactivity
9
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include N-Acetyl-L-cysteine?
N-Acetyl-L-cysteine appears on 4 regulatory/inventory lists including active_ingredient; animal_products; Europe; pharmaceutical; residue, pharmaceutical, Canada; pharmaceutical, and 1 more. Source: EPA CPDat.
Is N-Acetyl-L-cysteine used in cosmetics?
Yes, N-Acetyl-L-cysteine is also indexed as a cosmetic ingredient under the name ACETYL CYSTEINE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for N-Acetyl-L-cysteine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is N-Acetyl-L-cysteine used outside industrial chemicals?
N-Acetyl-L-cysteine also appears in cosmetics, pharmaceutical, food safety, cannabis databases.