Is ACETYL CYSTEINE safe in cosmetics?
ACETYL CYSTEINE has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted.
GOOD
Cosmetic Ingredient
ACETYL CYSTEINE
Also known as: L-Cysteine, N-acetyl-, Cysteine, N-acetyl-, L-, (2R)-2Acetamido-3-sulfanylpropanoic acid, Acetadote, Asist (+14 more)
ACETYL CYSTEINE (CAS 616-91-1) is a cosmetic cosmetic ingredient functioning as Antioxidant, Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
Function
Antioxidant, Skin Conditioning
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
(2R)-2-acetamido-3-sulfanylpropanoic acid
InChIKey
PWKSKIMOESPYIA-BYPYZUCNSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
CIR: SQ - IJT 36(Suppl. 1):17-56, 2017
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
JPKR Japan/Korea Cosmetics
Korea (Prohibited): Acetylcysteine; must not be used
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Softener and conditioner
Editorial summary
Preliminary editorial summary for ACETYL CYSTEINE — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
antioxidant
needs-enrichment
Known Synonyms
L-Cysteine, N-acetyl-
Cysteine, N-acetyl-, L-
(2R)-2Acetamido-3-sulfanylpropanoic acid
Acetadote
Asist
Brunac
Broncholysin (mucolytic)
Cysteplus
Exomuc
N-Acetyl-(R)-cysteine
Tixair
Trom
Acetylcysteine
ACC
Acetein
component of Naxid
EINECS 210-498-3
Mucolyticum Lappe
Mucosil
Chemical Function
Antioxidant
Softener and conditioner
Regulatory Lists
active_ingredient; animal_products; Europe; pharmaceutical; residue
pharmaceutical
pharmaceutical
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Canada; consumer_product; Substances in Products - Canada (4/2014)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ACETYLCYSTEINE
ChEMBL ID
CHEMBL600
Max Phase
4
Adverse Event Associations
3000
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
N-Acetylcysteine
Food Category
preservative
Frequently Asked Questions
Is ACETYL CYSTEINE allowed in the EU?
ACETYL CYSTEINE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does ACETYL CYSTEINE do in cosmetics?
ACETYL CYSTEINE functions as: Antioxidant, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 616-91-1.
Is ACETYL CYSTEINE used outside cosmetics?
ACETYL CYSTEINE also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check ACETYL CYSTEINE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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