NOAEL Data Cosmetic Ingredient

3-Amino-2,4-dichlorophenol

Also known as: 1-Hydroxy-3-amino-2,4-dichlorobenzene, EINECS 262-909-0, UNII-551I6ZAE4Q

CAS 61693-42-3

3-Amino-2,4-dichlorophenol (CAS 61693-42-3) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS.

View cosmetic safety profile for 3-Amino-2,4-Dichlorophenol →

Cross-Vertical Regulatory Divergence

3-Amino-2,4-dichlorophenol is prohibited in EU cosmetics at max 2.0% but has active industrial GHS classifications.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 8 fields

Name

3-Amino-2,4-dichlorophenol

CAS Number

61693-42-3

Molecular Formula

C6H5Cl2NO

InChI Key

SYRZWFBWUASJJI-UHFFFAOYSA-N

Monoisotopic Mass

176.974819

Synonyms

1-Hydroxy-3-amino-2,4-dichlorobenzeneEINECS 262-909-0UNII-551I6ZAE4Q

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records

List	Keyword	Source
Europe	-	https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.simple
Personal care	-	https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.simple
restricted	-	https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.simple

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 16 of 16 studies

Value	Unit	Endpoint	Route	Species	Source
115	mg/kg bw/d	-	-	human	Regulatory source
115	mg/kg bw/d	-	-	-	Regulatory source
551I6ZAE4Q	UNII	FDA UNII substance identifier	-	-	openFDA substances
=0.41	mg/kg	NOAEL	oral	rat	SCCS Opinion
=0.74	mg/kg	NOAEL	oral	rat	SCCS Opinion
=80	mg/kg bw	NOAEL	oral	rat	SCCS Opinion
=80	mg/kg bw/d	NOAEL	dermal	rat	SCCS Opinion
=115	mg/kg bw/d	NOAEL	-	human	SCCS Opinion
=480	mg/kg bw/d	NOAEL	-	rat	SCCS Opinion
=2000	mg/kg bw	NOAEL	-	rat	SCCS Opinion
=0.41	mg/kg	dermal absorption	oral	rat	Regulatory source
=0.74	mg/kg	dermal absorption	oral	rat	Regulatory source
=80	mg/kg bw	dermal absorption	oral	rat	Regulatory source
80	mg/kg bw/d	dermal absorption	dermal	rat	Regulatory source
480	mg/kg bw/d	genotoxicity	-	rat	Regulatory source
2000	mg/kg bw	irritation	-	rat	Regulatory source

Showing 16 of 16 studies

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCP/1074/07	2007-03-21	The SCCP is of the opinion that the use of 3-amino-2,4-dichlorophenol HCl itself as an oxidative hair dye at a maximum concentration of 1.5% in the finished cosmetic product (after mixing with hydrogen peroxide) does not pose a risk to the health of the consumer, apart from its sensitising potential.	1.5%	Sensitising potential (moderate skin sensitiser). Clastogenic in vitro (V79 micronucleus), but no mutagenic potential in vivo; genotoxicity/mutagenicity studies on finished hair dye formulations still required. Severely irritating to rabbit eye.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

2.0%

Frequently Asked Questions

What is the NOAEL for 3-Amino-2,4-dichlorophenol?

3-Amino-2,4-dichlorophenol has 16 NOAEL studies in the database. The lowest reported value is 115 mg/kg bw/d in human. Source: Regulatory source.

What regulatory lists include 3-Amino-2,4-dichlorophenol?

3-Amino-2,4-dichlorophenol appears on 3 regulatory/inventory lists including Europe, Personal care, restricted. Source: EPA CPDat.

Is 3-Amino-2,4-dichlorophenol used in cosmetics?

Yes, 3-Amino-2,4-dichlorophenol is also indexed as a cosmetic ingredient under the name 3-Amino-2,4-Dichlorophenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 3-Amino-2,4-dichlorophenol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 3-Amino-2,4-dichlorophenol have different safety status in cosmetics vs industrial chemicals?

3-Amino-2,4-dichlorophenol is prohibited in EU cosmetics at max 2.0% but has active industrial GHS classifications.

Is 3-Amino-2,4-dichlorophenol used outside industrial chemicals?

3-Amino-2,4-dichlorophenol also appears in cosmetics databases.