Is 3-Amino-2,4-Dichlorophenol safe in cosmetics?
3-Amino-2,4-Dichlorophenol has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
3-Amino-2,4-Dichlorophenol
Also known as: 1-Hydroxy-3-amino-2,4-dichlorobenzene, EINECS 262-909-0, UNII-551I6ZAE4Q
INCI: 3-AMINO-2,4-DICHLOROPHENOL
3-Amino-2,4-Dichlorophenol (CAS 61693-42-3) is a cosmetic cosmetic ingredient functioning as Hair dyeing — oxidative hair dye precursor (COLIPA No. A43). Reported NOAEL =0.41 mg/kg in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: prohibited, max 2.0%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 61693-42-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
3-Amino-2,4-Dichlorophenol is prohibited in EU cosmetics at max 2.0% but has active industrial GHS classifications.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word
Function
Hair dyeing — oxidative hair dye precursor (COLIPA No. A43)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3-amino-2,4-dichlorophenol
InChIKey
SYRZWFBWUASJJI-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
EU Max Conc.
2.0%
US US Status
permitted
US Notes
Coal tar hair dye exemption under FD&C Act §601(a); caution labeling required
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 3-Amino-2,4-Dichlorophenol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for 3-Amino-2,4-Dichlorophenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.41 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.41 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.41 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.41 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.74 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.74 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.74 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.74 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =80 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =80 mg/kg bw/d | dermal | rat | dermal absorption | SCCS_vision_codex |
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (2 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| default | 1.5% | - | - | SCCP/0092 |
| default | 1.5% | - | - | SCCP/0150 |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Expert Verdict
Expert safety assessment and concern-level summary for 3-Amino-2,4-Dichlorophenol.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 3-Amino-2,4-Dichlorophenol by CAS number or substance name.
Studies
28
Lowest NOAEL
0.41
Highest NOAEL
2000
Units vary across source rows: mg/kg bw/d, mg/kg, mg/kg bw
SCCS_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 1.5% | - | - |
| 1.5% | - | - |
Known Synonyms
1-Hydroxy-3-amino-2,4-dichlorobenzene
EINECS 262-909-0
UNII-551I6ZAE4Q
Chemical Function
Dye
Regulatory Lists
Europe
Personal care
restricted
Frequently Asked Questions
Is 3-Amino-2,4-Dichlorophenol allowed in the EU?
3-Amino-2,4-Dichlorophenol EU regulatory status: prohibited. Maximum allowed concentration: 2.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does 3-Amino-2,4-Dichlorophenol do in cosmetics?
3-Amino-2,4-Dichlorophenol functions as: Hair dyeing — oxidative hair dye precursor (COLIPA No. A43). It is classified as a cosmetic ingredient in our database. CAS number: 61693-42-3.
What is the NOAEL for 3-Amino-2,4-Dichlorophenol?
The NOAEL (No Observed Adverse Effect Level) for 3-Amino-2,4-Dichlorophenol is =0.41 mg/kg based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Is 3-Amino-2,4-Dichlorophenol used outside cosmetics?
3-Amino-2,4-Dichlorophenol also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 3-Amino-2,4-Dichlorophenol have different safety status in cosmetics vs industrial chemicals?
3-Amino-2,4-Dichlorophenol is prohibited in EU cosmetics at max 2.0% but has active industrial GHS classifications.
Compliance Tools
Check 3-Amino-2,4-Dichlorophenol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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