What is the NOAEL for Cocamidopropyl betaine?
Cocamidopropyl betaine has 35 NOAEL studies in the database. The lowest reported value is 0 % via Dermal. Source: NTP ICE skin sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Cocamidopropyl betaine
Also known as: Alkateric Cab-A, Coco Amido Betaine, EINECS 263-058-8, UNII-5OCF3O11KX, Cocamidopropyl betaine (CAPB) (+1 more)
CAS 61789-40-0
Cocamidopropyl betaine (CAS 61789-40-0) is a chemical substance. Key regulatory status: REACH registered, 20 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Cocamidopropyl betaine is classified GHS Danger (H315, H318, H319, H400, H412) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
35
SOURCE
Chemical inventory jurisdictions
Regulatory lists
20
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
9 fields
Name
Cocamidopropyl betaine
CAS Number
61789-40-0
DTXSID
DTXSID6028072
Synonyms
Alkateric Cab-ACoco Amido BetaineEINECS 263-058-8UNII-5OCF3O11KXCocamidopropyl betaine (CAPB)CAPB
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Surfactant (surface active agent)Anti-static agentSoftener and conditionerViscosity modifierCleaning agentFoamantThickening agentEmulsifier
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
20 records
| List | Keyword | Source |
|---|---|---|
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - body hygiene - hand soap | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - body hygiene - body wash | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bubble bath | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Cleaning products and household care - oven - oven cleaner; Europe | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair styling and care - shampoo-dandruff | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Cleaning products and household care; Europe | Danish EPA | Danish EPA |
| fracking; water | NY Department of Conservation | CPCat |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; Europe | Danish EPA | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 35 of 35 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 500 | mg/kg | - | - | rat | Regulatory source |
| range1.449 | ug/mL | CD86, EC120 | Dermal | - | NTP ICE skin sensitization |
| =8.22 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 3.9 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| - | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| range31.1 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| >35 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 5OCF3O11KX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5OCF3O11KX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5OCF3O11KX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5OCF3O11KX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| <1.16 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| =300 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB HPVIS |
| =1000 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB HPVIS |
| =95 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =250 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =250 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB HPVIS |
| =250 | mg/kg | NOAEL | dermal | rat | CIR Safety Assessment |
| =250 | mg/kg | NOAEL | dermal | rat | CIR Safety Assessment |
| =250 | mg/kg | NOAEL | dermal | rat | CIR Safety Assessment |
| =250 | mg/kg | NOAEL | dermal | rat | CIR Safety Assessment |
| =286 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =500 | mg/kg | NOAEL | - | rat | CIR Safety Assessment |
| =500 | mg/kg | NOAEL | - | rat | CIR Safety Assessment |
| =500 | mg/kg | NOAEL | - | rat | CIR Safety Assessment |
| =500 | mg/kg | NOAEL | - | rat | CIR Safety Assessment |
| >950 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| 250 | mg/kg | repeated dose toxicity | dermal | rat | Regulatory source |
| 500 | mg/kg | repeated dose toxicity | oral | rat | Regulatory source |
Showing 35 of 35 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1-Propanaminium, 3-amino-N-(carboxymethyl)-N,N-dimethyl-, N-coco acyl derivs., hydroxides, inner salts | 263-058-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
surfactant
Frequently Asked Questions
What regulatory lists include Cocamidopropyl betaine?
Cocamidopropyl betaine appears on 17 regulatory/inventory lists including SCIL (9/2019), Europe; Vehicle - car interior, Europe; Personal care - body hygiene - hand soap, and 14 more. Source: EPA CPDat.
Is Cocamidopropyl betaine used in cosmetics?
Yes, Cocamidopropyl betaine is also indexed as a cosmetic ingredient under the name Cocamidopropyl Betaine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Cocamidopropyl betaine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does Cocamidopropyl betaine have different safety status in cosmetics vs industrial chemicals?
Cocamidopropyl betaine is classified GHS Danger (H315, H318, H319, H400, H412) in the chemicals database but is allowed in EU cosmetics.
Is Cocamidopropyl betaine used outside industrial chemicals?
Cocamidopropyl betaine also appears in cosmetics databases.