Moderate Surfactant SCCS/CIR Reviewed Sensitization Data Dermal Penetration

Cocamidopropyl Betaine

INCI: COCAMIDOPROPYL BETAINE

CAS Number
61789-40-0
Function
Surfactant; foam booster; co-surfactant; viscosity builder
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR assessed safe as used at up to 30%. Named Allergen of the Year 2004 by American Contact Dermatitis Society. True sensitizers are manufacturing impurities DMAPA and amidoamine โ€” not CAPB itself. High-purity grades with <5 ppm DMAPA/amidoamine significantly reduce sensitization risk. 6 of 9 patch-test-positive subjects reacted to amidoamine at 0.1% aqueous.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir
Verdict: unknown
NOAEL: 500 mg/kg (not specified)
cir
Verdict: unknown
NOAEL: 250 mg/kg (oral)

Sensitization Profile

Contact sensitization data for Cocamidopropyl Betaine based on clinical patch test studies and IFRA standards.

Sensitization Rate
moderate
Allergen Class
surfactant
EU Allergen Listed
no
Patch Test Positive Rate
3.0%
Cross-reactivity Group
amidoamine-group
Reaction Type
contact-dermatitis

Source: NACDG; IVDK; ESSCA

Dermal Penetration Profile

Skin absorption and penetration characteristics of Cocamidopropyl Betaine, relevant to systemic exposure and MoS calculations.

Absorption %
6-12%
Penetration Level
stratum-corneum
Penetration Depth
stratum corneum/epidermis
Molecular Weight
342.5 Da
Log P
0.5
Systemic Absorption
minimal
Topical Bioavailability
4-10%
Safety Margin Factor
moderate
Vehicle Dependent
Yes โ€” absorption varies by formulation

Source: CIR

Expert Verdict

The most widely used co-surfactant in personal care; amphoteric betaine providing foam boosting, viscosity building, and mildness enhancement in SLES-based systems. CIR confirms safety at up to 30%. Sensitization risk (Allergen of the Year 2004) is impurity-driven by DMAPA and amidoamine, not CAPB itself; high-purity grades (<5 ppm impurities) substantially reduce risk.

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Concern Level: Moderate

Regulatory Flags

allergen-of-the-year-2004 sensitizer impurity-concern amphoteric foam-booster eu_children_restricted epa_safer_alternative

Frequently Asked Questions

Is Cocamidopropyl Betaine safe in cosmetics?

The most widely used co-surfactant in personal care; amphoteric betaine providing foam boosting, viscosity building, and mildness enhancement in SLES-based systems. CIR confirms safety at up to 30%. Sensitization risk (Allergen of the Year 2004) is impurity-driven by DMAPA and amidoamine, not CAPB itself; high-purity grades (<5 ppm impurities) substantially reduce risk. The EU classifies Cocamidopropyl Betaine as "permitted". Safety rating: MODERATE. This ingredient has been reviewed by cir.

Is Cocamidopropyl Betaine allowed in the EU?

Cocamidopropyl Betaine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Cocamidopropyl Betaine do in cosmetics?

Cocamidopropyl Betaine functions as: Surfactant; foam booster; co-surfactant; viscosity builder. It is classified as a Surfactant in our database. CAS number: 61789-40-0.

What is the Margin of Safety for Cocamidopropyl Betaine?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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