Also known as: Alkateric Cab-A, Coco Amido Betaine, EINECS 263-058-8, UNII-5OCF3O11KX, Cocamidopropyl betaine (CAPB) (+1 more)
INCI: COCAMIDOPROPYL BETAINE
Cocamidopropyl Betaine (CAS 61789-40-0) is a cosmetic surfactant functioning as Surfactant; foam booster; co-surfactant; viscosity builder. Reported NOAEL =95 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: permitted; 2 safety opinions reviewed (CIR Safety Assessment). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 61789-40-0 →
Cocamidopropyl Betaine is classified GHS Danger (H315, H318, H319, H400, H412) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Cocamidopropyl Betaine.
Calculate MoS for your specific formulation with the MoS Calculator.
3 study endpoints found for Cocamidopropyl Betaine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =95 mg/kg bw/day | oral | Rat | reproduction developmental | ECHA |
| NOAEL | =286 mg/kg bw/day | oral | Rat | developmental | ECHA |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | reproduction developmental | ECHA |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Contact sensitization data for Cocamidopropyl Betaine based on clinical patch test studies and IFRA standards.
Source: NACDG; IVDK; ESSCA
Skin absorption and penetration characteristics of Cocamidopropyl Betaine, relevant to systemic exposure and MoS calculations.
Source: CIR Expert Panel
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >2000 mg/kg | Rat | dermal | - | ECHA |
| NOAEL | =286 mg/kg-day | Rat | oral | - | ECHA |
| NOAEL | =95 mg/kg-day | Rat | oral | - | ECHA |
| NOAEL | =250 mg/kg-day | Rat | oral | subchronic | ECHA |
| NOAEL | =250 mg/kg-day | Rat | oral | subchronic | ECHA |
| NOAEL | =500 mg/kg-day | Rat | oral | short-term | ECHA |
| NOAEL | =500 mg/kg-day | Rat | oral | short-term | ECHA |
| LOAEL | =1000 mg/kg-day | Rat | oral | short-term | HPVIS |
| NOAEL | =500 mg/kg-day | Rat | oral | short-term | HPVIS |
| NOAEL | =250 mg/kg-day | Rat | oral | chronic | HPVIS |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Shampoo | 3–8 | 15 | CIR Safety Assessment |
| Body Wash | 3–8 | 15 | CIR Safety Assessment |
| Facial Cleanser | 2–6 | 10 | CIR Safety Assessment |
Preliminary editorial summary for Cocamidopropyl Betaine — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to Cocamidopropyl Betaine by CAS number or substance name.
Cocamidopropyl Betaine has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 3 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by CIR Safety Assessment.
Cocamidopropyl Betaine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Cocamidopropyl Betaine functions as: Surfactant; foam booster; co-surfactant; viscosity builder. It is classified as a Surfactant in our database. CAS number: 61789-40-0.
The NOAEL (No Observed Adverse Effect Level) for Cocamidopropyl Betaine is =95 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 3 study endpoints are available. Source: ECHA.
Cocamidopropyl Betaine also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Cocamidopropyl Betaine is classified GHS Danger (H315, H318, H319, H400, H412) in the chemicals database but is allowed in EU cosmetics.
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