What is the NOAEL for Dihydroergotamine mesylate?
Dihydroergotamine mesylate has 7 NOAEL studies in the database. The lowest reported value is developmental listing type. Source: California Proposition 65.
NOAEL Data
Prop 65
Cosmetic Ingredient
Dihydroergotamine mesylate
Also known as: Dihydroergotamine methanesulfonate, Dihydroergotamine methanesulfonate salt, Ergotamine, 9,10-dihydro-, monomethanesulfonate (salt), Ergotoman-3',6',18-trione,9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha)-, monomethanesulfonate (salt)
CAS 6190-39-2
Dihydroergotamine mesylate (CAS 6190-39-2) is a chemical substance; key hazard signal: developmental. Key regulatory status: California Proposition 65, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, CA Prop 65.
Cross-Vertical Regulatory Divergence
Dihydroergotamine mesylate is prohibited in EU cosmetics but has active industrial GHS classifications (H312, H332).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
10 fields
Name
Dihydroergotamine mesylate
CAS Number
6190-39-2
DTXSID
DTXSID00904615
Molecular Formula
C33H37N5O5.CH4O3S
InChI Key
ADYPXRFPBQGGAH-UMYZUSPBSA-N
Monoisotopic Mass
679.267584
Synonyms
Dihydroergotamine methanesulfonateDihydroergotamine methanesulfonate saltErgotamine, 9,10-dihydro-, monomethanesulfonate (salt)Ergotoman-3',6',18-trione,9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha)-, monomethanesulfonate (salt)
California Proposition 65
California OEHHA listing status and toxicity category.
SOURCE
California OEHHA Proposition 65 List
1 records
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | developmental | No | Yes | - |
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| FRdevelopmental | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| FRdevelopmental | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| FRdevelopmental | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| 81AXN7R2QT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 81AXN7R2QT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 81AXN7R2QT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 81AXN7R2QT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 7 of 7 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Synthetic Polymers
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DIHYDROERGOTAMINE MESYLATE
ChEMBL Phase
4
Adverse Events
2
Bioactivity
4
Frequently Asked Questions
What regulatory lists include Dihydroergotamine mesylate?
Dihydroergotamine mesylate appears on 1 regulatory/inventory list including OEHHA Proposition 65 (1/2023). Source: EPA CPDat.
Is Dihydroergotamine mesylate on the California Proposition 65 list?
Yes, Dihydroergotamine mesylate is listed under California Proposition 65 for developmental. Source: California OEHHA Proposition 65.
Is Dihydroergotamine mesylate used in cosmetics?
Yes, Dihydroergotamine mesylate is also indexed as a cosmetic ingredient under the name Dihydroergotamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dihydroergotamine mesylate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, California Proposition 65, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Dihydroergotamine mesylate have different safety status in cosmetics vs industrial chemicals?
Dihydroergotamine mesylate is prohibited in EU cosmetics but has active industrial GHS classifications (H312, H332).
Is Dihydroergotamine mesylate used outside industrial chemicals?
Dihydroergotamine mesylate also appears in cosmetics, pharmaceutical databases.