Is Dihydroergotamine safe in cosmetics?
Dihydroergotamine has a safety rating of "POOR" in our database. EU status: prohibited. US status: prohibited.
POOR
Cosmetic Ingredient
Dihydroergotamine
Also known as: Dihydroergotamine methanesulfonate, Dihydroergotamine methanesulfonate salt, Ergotamine, 9,10-dihydro-, monomethanesulfonate (salt), Ergotoman-3',6',18-trione,9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha)-, monomethanesulfonate (salt)
INCI: DIHYDROERGOTAMINE
Dihydroergotamine (CAS 6190-39-2) is a cosmetic cosmetic ingredient functioning as Not for cosmetic use. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Cross-Vertical Regulatory Divergence
Dihydroergotamine is prohibited in EU cosmetics but has active industrial GHS classifications (H312, H332).
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Not for cosmetic use
Editorial assessment
POOR
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
(6aR,9R,10aR)-N-[(1S,2S,4R,7S)-7-benzyl-2-hydroxy-4-methyl-5,8-dioxo-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide;methanesulfonic acid
InChIKey
ADYPXRFPBQGGAH-UMYZUSPBSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
Pharmaceutical drug (ergot alkaloid); not approved for cosmetic use in the US
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dihydroergotamine.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Regulatory List Membership (1)
California Proposition 65 (OEHHA)
Editorial summary
Preliminary editorial summary for Dihydroergotamine — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
pharmaceutical
prohibited-EU
not-cosmetic
ergot-alkaloid
prop65
Known Synonyms
Dihydroergotamine methanesulfonate
Dihydroergotamine methanesulfonate salt
Ergotamine, 9,10-dihydro-, monomethanesulfonate (salt)
Ergotoman-3',6',18-trione,9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha)-, monomethanesulfonate (salt)
Regulatory Lists
OEHHA Proposition 65 (1/2023)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DIHYDROERGOTAMINE MESYLATE
ChEMBL ID
CHEMBL1200517
Max Phase
4
Adverse Event Associations
2
Frequently Asked Questions
Is Dihydroergotamine allowed in the EU?
Dihydroergotamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Dihydroergotamine do in cosmetics?
Dihydroergotamine functions as: Not for cosmetic use. It is classified as a cosmetic ingredient in our database. CAS number: 6190-39-2.
Is Dihydroergotamine used outside cosmetics?
Dihydroergotamine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Dihydroergotamine have different safety status in cosmetics vs industrial chemicals?
Dihydroergotamine is prohibited in EU cosmetics but has active industrial GHS classifications (H312, H332).
Compliance Tools
Check Dihydroergotamine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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