Also known as: Benzenamine, C.I. Oxidation Base 1, Aniline oil, Arylamine, Benzene, amino (+15 more)
CAS 62-53-3
Aniline (CAS 62-53-3) is a chemical substance with GHS signal word Danger; key hazard signal: H351; H341; H331; H311; H301; H372 **; H318; H317; H400. Key regulatory status: California Proposition 65, REACH registered, 22 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, IARC, ECHA REACH, CA Prop 65, ILO ICSC, OSHA, EPA TRI.
Aniline is classified GHS Danger (H351, H341, H331, H311, H301, H372, H318, H317) in the chemicals database but is restricted in EU cosmetics at max II/22 CMR2.
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2A | Probably carcinogenic | 2020 | 27, Sup 7, 127 |
California OEHHA listing status and toxicity category.
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Carc. 2; Muta. 2; Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; STOT RE 1; Eye Dam. 1; Skin Sens. 1; Aquatic Acute 1 | H351; H341; H331; H311; H301; H372 **; H318; H317; H400 | GHS08; GHS06; GHS05; GHS09 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Toxic if swallowed, in contact with skin or if inhaled Causes damage to red blood cells Causes damage to the blood through prolonged or repeated exposure Causes serious eye irritation May cause an allergic skin reaction Very toxic to aquatic life |
| Short-term Effects | The substance is severely irritating to the eyes. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. See Notes. Exposure could cause haemolysis. This may result in haemolytic anaemia. The effects may be delayed. Medical observation is indicated. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the blood. This may result in haemolytic anaemia. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, through the skin also as a vapour and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 5 ppm (19 mg/m³) | 5 | 19 | Y |
| CAL/OSHA | TWA | 2 ppm (7.6 mg/m³) | 2 | 7.6 | Y |
| NIOSH | IDLH | 100 ppm | 100 | - | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| detected; Europe; Other indirect contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; emissions; Europe; Other indirect contact consumer goods; water | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Europe; nondetect; Road vehicles | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| - | Mutation Research/Reviews in Genetic Toxicology | Published Articles |
| children; WA Children's Safe Product Act (4/2020) | State of Washington Department of Ecology | State of Washington |
| Canada; pharmaceutical | DrugBank | DrugBank |
| children | Vermont Department of Health | State of Vermont |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
| children | Oregon Health Authority | State of Oregon |
| banned; Europe; Personal care | European Commission | CosIng |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| ~29 | mg/kg bw/day | BMDL (10) | oral | Rat | ToxValDB_EFSA |
| 550.8 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 70.974 | ug/mL | CD86, EC120 | Dermal | - | NTP_ICE_skin_sensitization |
| 31.003 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 62.5 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 280 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 927.9 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| >200 | ug/mL | CV70 | Dermal | - | NTP_ICE_skin_sensitization |
| 403.2 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 930 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| AB100 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| AB100 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| AB100 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| 3.571 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2.857 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| =7.7 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| -1 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.3 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 2.4 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 9.7 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.15 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.7 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 4.9 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 2 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 13.25 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 13.25 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 13.25 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 13.25 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 16.6 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 16.6 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 16.6 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 16.6 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 50 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 50 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 50 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 50 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 89 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 89 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 89 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 89 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| SIR7XX2F1K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| SIR7XX2F1K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| SIR7XX2F1K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| SIR7XX2F1K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2A | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
Showing 50 of 80 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Aniline | 200-539-3 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| Aniline | - | - |
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Aniline (CAS 62-53-3) is classified under EU CLP Annex VI as Carc. 2; Muta. 2; Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; STOT RE 1; Eye Dam. 1; Skin Sens. 1; Aquatic Acute 1 with signal word Danger. Hazard statements: H351; H341; H331; H311; H301; H372 **; H318; H317; H400. Source: EU CLP Annex VI (ECHA).
Aniline has 80 NOAEL studies in the database. The lowest reported value is -1 % via Dermal. Source: NTP_ICE_skin_sensitization.
Aniline appears on 14 regulatory/inventory lists including Indirect additives food contact (10/2018), OEHHA Proposition 65 (3/2019), detected; Europe; Other indirect contact consumer goods, and 11 more. Source: EPA CPDat.
Aniline is classified by IARC as Group 2A — probably carcinogenic to humans (evaluated 2020). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Yes, Aniline is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Occupational exposure limits for Aniline are set by OSHA, CAL/OSHA, NIOSH. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Aniline is also indexed as a cosmetic ingredient under the name ANILINE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Aniline is classified GHS Danger (H351, H341, H331, H311, H301, H372, H318, H317) in the chemicals database but is restricted in EU cosmetics at max II/22 CMR2.
Aniline also appears in cosmetics, pharmaceutical, cannabis databases.