ANILINE

ANILINE is listed in the EU CosIng database with functions: Not Reported It is restricted under EU Cosmetics Regulation. Restriction: II/22 CMR2. The EU classifies ANILINE as "Restricted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.

ANILINE EU regulatory status: Restricted. Maximum allowed concentration: II/22 CMR2. This is based on EU Regulation 1223/2009 and its amendments.

ANILINE functions as: Not Reported. It is classified as a cosmetic ingredient in our database. CAS number: 62-53-3.

NOAEL: No single cosmetic‑use NOAEL; multiple repeated‑dose studies show haematological effects at low doses. Canadian assessment reports haematological changes at 10–30 mg/kg bw/day in animals and identifies critical effects, but does not clearly state a numeric NOAEL in the summary text retrieved . Some rabbit dermal lethality studies report non‑lethal doses around 838–2200 mg/kg on abraded/i... The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

The NOAEL (No Observed Adverse Effect Level) for ANILINE is 4 other based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.

ANILINE carries a GHS signal word of "DANGER". Hazard statements: Toxic if swallowed, in contact with skin or if inhaled Causes damage to red blood cells Causes damage to the blood through prolonged or repeated exposure Causes serious eye irritation May cause an allergic skin reaction Very toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.