What is the GHS hazard classification for Hexyl salicylate?
Hexyl salicylate (CAS 6259-76-3) is classified under EU CLP Annex VI as Repr. 2; Skin Sens. 1 with signal word Warning. Hazard statements: H361d; H317. Source: EU CLP Annex VI (ECHA).
Warning
GHS08GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
Hexyl salicylate
Also known as: Benzoic acid, 2-hydroxy-, hexyl ester, Salicylic acid, hexyl ester, 1-Hexyl salicylate, n-Hexyl-o-hydroxybenzoate, EINECS 228-408-6 (+3 more)
CAS 6259-76-3
Hexyl salicylate (CAS 6259-76-3) is a chemical substance with GHS signal word Warning; key hazard signal: H361d; H317. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Hexyl salicylate is classified GHS CMR hazard (H361d, H317) in the chemicals database but is restricted in EU cosmetics at max 2% hydroalcoholic fragrances, 0.5% rinse-off, 0.3% leave-on, 0.001% oral care.
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Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
100
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chemical inventory jurisdictions
Regulatory lists
7
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eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
14 fields
Name
Hexyl salicylate
CAS Number
6259-76-3
DTXSID
DTXSID4038924
Molecular Formula
C13H18O3
InChI Key
DUKPKQFHJQGTGU-UHFFFAOYSA-N
Monoisotopic Mass
222.125594
Synonyms
Benzoic acid, 2-hydroxy-, hexyl esterSalicylic acid, hexyl ester1-Hexyl salicylaten-Hexyl-o-hydroxybenzoateEINECS 228-408-6Hexyl 2-hydroxybenzoaten-Hexyl salicylateUNII-8F78EY72YL
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Repr. 2; Skin Sens. 1 | H361d; H317 | GHS08; GHS07 | Warning |
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
60 records
FragranceDeodorizerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| consumer_product | P&G | Proctor & Gamble |
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 3 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 13 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 13.4 | % | - | dermal | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 15 | - | - | oral | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 75 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 180 | mg/kg bw/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 180 | mg/kg bw/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 180 | mg/kg bw/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 180 | mg/kg bw/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 370 | mg/kg bw/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 370 | mg/kg bw/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 370 | mg/kg bw/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 540 | mg/kg bw/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 540 | mg/kg bw/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 540 | mg/kg bw/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 736 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 801 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 822 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 1000 | mg/kg bw/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 1668 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =75000 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 57.7292004099647 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 47.5953167173507 | uM | ACC | - | - | NTP_ICE_endocrine |
| 52.73 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 27.29 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 147.7 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 191.4 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =1.7 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 3.9 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 1.1 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| >2000 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 4000 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 0.2 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 0.2 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 0.2 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 0.2 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 8F78EY72YL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8F78EY72YL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8F78EY72YL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8F78EY72YL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 53.7 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 67.4 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 1.37 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.5 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2025 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 35430 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0173 | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Hexyl salicylate | 228-408-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
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EU SCCS
2 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1668/24 | 25 October 2024 | Safe with restrictions for children ≤3 years old | 0.1% shower gels/hand soaps/shampoos/conditioners/body lotions/face creams/hand creams/lip products/fine fragrance; 0.001% toothpaste | CMR Cat.2 (reprotoxic); skin sensitiser Cat.1; salicylic acid metabolite not permitted in <3yr cosmetics; enhanced uptake through damaged skin |
| SCCS/1658/23 | 28 February 2024 | Safe with restrictions | 2% hydroalcoholic fragrances; 0.5% rinse-off products; 0.3% leave-on products; 0.001% oral care products | CMR Cat.2 (reprotoxic); skin sensitiser Cat.1B; potential endocrine disrupting properties; salicylic acid metabolite |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
2% hydroalcoholic fragrances, 0.5% rinse-off, 0.3% leave-on, 0.001% oral care
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
2-HYDROXYBENZOIC ACID HEXYL ESTER
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Hexyl salicylate?
Hexyl salicylate has 100 NOAEL studies in the database. The lowest reported value is 0 fraction in Human. Source: NTP_ICE_adme_parameters.
What regulatory lists include Hexyl salicylate?
Hexyl salicylate appears on 7 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, IFRA Transparency, Europe, and 4 more. Source: EPA CPDat.
Is Hexyl salicylate used in cosmetics?
Yes, Hexyl salicylate is also indexed as a cosmetic ingredient under the name Hexyl Salicylate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Hexyl salicylate come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Hexyl salicylate have different safety status in cosmetics vs industrial chemicals?
Hexyl salicylate is classified GHS CMR hazard (H361d, H317) in the chemicals database but is restricted in EU cosmetics at max 2% hydroalcoholic fragrances, 0.5% rinse-off, 0.3% leave-on, 0.001% oral care.
Is Hexyl salicylate used outside industrial chemicals?
Hexyl salicylate also appears in cosmetics, pharmaceutical, cannabis databases.