Also known as: Benzoic acid, 2-hydroxy-, hexyl ester, Salicylic acid, hexyl ester, 1-Hexyl salicylate, n-Hexyl-o-hydroxybenzoate, EINECS 228-408-6 (+3 more)
INCI: HEXYL SALICYLATE
Hexyl Salicylate (CAS 6259-76-3) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient with sweet, floral, fruity odour. NOAEL 75 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 2% hydroalcoholic fragrances, 0.5% rinse-off, 0.3% leave-on, 0.001% oral care; 5 safety opinions reviewed (sccs). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 6259-76-3 →
Hexyl Salicylate is classified GHS CMR hazard (H315, H317, H319, H400, H410, H361d) in the chemicals database but is restricted in EU cosmetics at max 2% hydroalcoholic fragrances, 0.5% rinse-off, 0.3% leave-on, 0.001% oral care.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexyl Salicylate.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for Hexyl Salicylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =29 mg/kg/day | - | rat | reproductive toxicity | SCCS_vision_codex |
| NOAEL | =29 mg/kg/day | - | rat | reproductive toxicity | SCCS_vision_codex |
| NOAEL | =29 mg/kg/day | - | rat | reproductive toxicity | SCCS_vision_codex |
| NOAEL | =29 mg/kg/day | - | rat | reproductive toxicity | SCCS_vision_codex |
| NOAEL | =75 mg/kg bw/day | oral | human | developmental toxicity | SCCS_vision_codex |
| NOAEL | =75 mg/kg bw/day | oral | human | developmental toxicity | SCCS_vision_codex |
| NOAEL | =75 mg/kg/day | - | rat | reproductive toxicity | SCCS_vision_codex |
| NOAEL | =75 mg/kg bw/day | oral | human | developmental toxicity | SCCS_vision_codex |
| NOAEL | =75 mg/kg/day | - | rat | reproductive toxicity | SCCS_vision_codex |
| NOAEL | =75 mg/kg bw/day | oral | human | developmental toxicity | SCCS_vision_codex |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
ed to potential endocrine disrupting properties, the SCCS considers Hexyl Salicylate safe when used up to the maximum concentrations as provided in Table 1 of this Opinion. Product type, Body parts Maximum concentration (% w/w) Hydroalcoholic-based fragrances 2 All Rinse-off prod
ed to potential endocrine disrupting properties, the SCCS considers Hexyl Salicylate safe when used up to the maximum concentrations as provided in Table 1 of this Opinion. Product type, Body parts Maximum concentration (% w/w) Hydroalcoholic-based fragrances 2 All Rinse-off prod
ed to potential endocrine disrupting properties, the SCCS considers Hexyl Salicylate safe when used up to the maximum concentrations as provided in Table 1 of this Opinion. Product type, Body parts Maximum concentration (% w/w) Hydroalcoholic-based fragrances 2 All Rinse-off prod
ncluding potential endocrine disrupting effects, the SCCS considers Hexyl Salicylate safe for children up to 3 years old when used up to the maximum concentrations as below: o 0.1 % (w/w) for shower gel, hand soap, shampoo, hair conditioner, body lotion, face cream, hand cream, lips
ncluding potential endocrine disrupting effects, the SCCS considers Hexyl Salicylate safe for children up to 3 years old when used up to the maximum concentrations as below: o 0.1 % (w/w) for shower gel, hand soap, shampoo, hair conditioner, body lotion, face cream, hand cream, lips
Pre-calculated NOAEL → SED → MoS audit trail for Hexyl Salicylate across SCCS product categories, with measured dermal absorption where available.
NOAEL/LOAEL values cited in official SCCS opinions for Hexyl Salicylate.
| NOAEL | LOAEL | Route | Species | Study | DA% (SCCS) | Opinion |
|---|---|---|---|---|---|---|
| 75 mg/kg/day | 165 mg/kg/day | Oral | Rat (Wistar) | Developmental toxicity (read-across from salicylic acid) (GD 8-14 (gestational days)) | 100 | SCCS/1658/23 (2024) |
Contact sensitization data for Hexyl Salicylate based on clinical patch test studies and IFRA standards.
Source: EU 2023/1545; SCCS
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Inserted via ATP: ATP22
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
Source: LLNA: RIFM (RIFM DB #51636) | Kern et al. (2010); DPRA: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008] | Unilever commissioned, Covance; KS: No reference provided in NICEATM database | Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008]; hCLAT: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008] | Unilever commissioned, IIVS; HPPT: [475] Epstein WL (1975): Report to RIFM, 31 January, unpublished.
4 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 103 | 0 | 35430 | 35430 | non-sensitizer |
| HMT | - | 0 | 2025 | - | - |
| HRIPT | - | 0 | 35433.07 | - | - |
| OECD_DA_Human | - | 0 | - | - | Non-sensitizer |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| UK | restricted | - | - |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 100.0 | method=measured; type=in_vitro | - | - |
| default | 4.47 | method=default | - | - |
| default | 13.4 | method=default | - | - |
| measured | 10.5 | method=measured | - | - |
| measured | 13.4 | method=measured; type=in_vitro | - | - |
International Fragrance Association standards per product category. Restriction: Restriction. Effective: 2021-02-10.
| Category | Max % | Category | Max % |
|---|---|---|---|
| 1 (Lip products) | 0.1% | 7a (Deodorant – not spray) | 0.2% |
| 2 (Body spray) | 0.03% | 7b (Deodorant spray) | 0.2% |
| 3 (Body cream) | 0.1% | 8 (Face cream) | 0.033% |
| 4 (Fine fragrance) | 0.4% | 9 (Soap) | 0.5% |
| 5a (Body lotion) | 0.1% | 10a (Household – non-spray) | 0.5% |
| 5b (Face cream leave-on) | 0.1% | 10b (Household – spray) | No Restriction% |
| 5c (Hand cream) | 0.1% | 11a (Intimate – leave-on) | 0.033% |
| 5d (Baby cream) | 0.033% | 11b (Intimate – rinse) | 0.033% |
| 6 (Mouthwash) | 0.1% | 12 (Not for consumer exposure) | No Restriction% |
1 property record from structured ingredient metadata.
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Expert safety assessment and concern-level summary for Hexyl Salicylate.
Public NOAEL study rows linked to Hexyl Salicylate by CAS number or substance name.
Units vary across source rows: mg/kg bw/day, mg/kg, mg/kg/day
| Absorption % | Method | Vehicle |
|---|---|---|
| 100.0 | method=measured; type=in_vitro | - |
| 4.47 | method=default | - |
| 13.4 | method=default | - |
| 10.5 | method=measured | - |
| 13.4 | method=measured; type=in_vitro | - |
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
Hexyl Salicylate has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by sccs.
Hexyl Salicylate EU regulatory status: restricted. Maximum allowed concentration: 2% hydroalcoholic fragrances, 0.5% rinse-off, 0.3% leave-on, 0.001% oral care. This is based on EU Regulation 1223/2009 and its amendments.
Hexyl Salicylate functions as: Fragrance ingredient with sweet, floral, fruity odour. It is classified as a cosmetic ingredient in our database. CAS number: 6259-76-3.
The NOAEL (No Observed Adverse Effect Level) for Hexyl Salicylate is =29 mg/kg/day based on a reproductive toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Hexyl Salicylate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Hexyl Salicylate is classified GHS CMR hazard (H315, H317, H319, H400, H410, H361d) in the chemicals database but is restricted in EU cosmetics at max 2% hydroalcoholic fragrances, 0.5% rinse-off, 0.3% leave-on, 0.001% oral care.
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