Hexyl Salicylate
INCI: HEXYL SALICYLATE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Hexyl Salicylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =75 mg/kg/day | oral | rat | developmental | SCCS |
| NOAEL | 180 mg/kg bw/day | - | - | reproductive | SCCS_PDF_extraction |
| NOAEL | 75 mg/kg bw/day | oral | - | - | SCCS_PDF_extraction |
| NOAEL | 1127 mg/kg bw/day | oral | - | - | SCCS_PDF_extraction |
| NOAEL | 1000 mg/kg bw/day | oral | - | - | SCCS_PDF_extraction |
| NOAEL | 370 mg/kg bw/day | - | - | - | SCCS_PDF_extraction |
| NOAEL | 540 mg/kg bw/day | - | - | reproductive | SCCS_PDF_extraction |
| NOAEL | 75 mg/kg bw/day | - | - | - | SCCS_PDF_extraction |
| NOAEL | 180 mg/kg bw/day | - | - | reproductive | SCCS_PDF_extraction |
| NOAEL | 75 mg/kg bw/day | oral | - | - | SCCS_PDF_extraction |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
ed to potential endocrine disrupting properties, the SCCS considers Hexyl Salicylate safe when used up to the maximum concentrations as provided in Table 1 of this Opinion. Product type, Body parts Maximum concentration (% w/w) Hydroalcoholic-based fragrances 2 All Rinse-off prod
ed to potential endocrine disrupting properties, the SCCS considers Hexyl Salicylate safe when used up to the maximum concentrations as provided in Table 1 of this Opinion. Product type, Body parts Maximum concentration (% w/w) Hydroalcoholic-based fragrances 2 All Rinse-off prod
ed to potential endocrine disrupting properties, the SCCS considers Hexyl Salicylate safe when used up to the maximum concentrations as provided in Table 1 of this Opinion. Product type, Body parts Maximum concentration (% w/w) Hydroalcoholic-based fragrances 2 All Rinse-off prod
ncluding potential endocrine disrupting effects, the SCCS considers Hexyl Salicylate safe for children up to 3 years old when used up to the maximum concentrations as below: o 0.1 % (w/w) for shower gel, hand soap, shampoo, hair conditioner, body lotion, face cream, hand cream, lips
ncluding potential endocrine disrupting effects, the SCCS considers Hexyl Salicylate safe for children up to 3 years old when used up to the maximum concentrations as below: o 0.1 % (w/w) for shower gel, hand soap, shampoo, hair conditioner, body lotion, face cream, hand cream, lips
SCCS NOAEL Values
NOAEL/LOAEL values cited in official SCCS opinions for Hexyl Salicylate.
| NOAEL | LOAEL | Route | Species | Study | DA% (SCCS) | Opinion |
|---|---|---|---|---|---|---|
| 75 mg/kg/day | 165 mg/kg/day | Oral | Rat (Wistar) | Developmental toxicity (read-across from salicylic acid) (GD 8-14 (gestational days)) | 100 | SCCS/1658/23 (2024) |
Sensitization Profile
Contact sensitization data for Hexyl Salicylate based on clinical patch test studies and IFRA standards.
Source: EU 2023/1545; SCCS
Expert Verdict
Restricted ingredient with toxicity for reproduction (Category 2 suspected) and skin sensitization (Category 1); potential endocrine disrupting properties under evaluation with concentration limits applied across product categories.
Regulatory Flags
Frequently Asked Questions
Is Hexyl Salicylate safe in cosmetics?
Restricted ingredient with toxicity for reproduction (Category 2 suspected) and skin sensitization (Category 1); potential endocrine disrupting properties under evaluation with concentration limits applied across product categories. The EU classifies Hexyl Salicylate as "restricted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by sccs.
Is Hexyl Salicylate allowed in the EU?
Hexyl Salicylate EU regulatory status: restricted. Maximum allowed concentration: 2% hydroalcoholic fragrances, 0.5% rinse-off, 0.3% leave-on, 0.001% oral care. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexyl Salicylate do in cosmetics?
Hexyl Salicylate functions as: Fragrance ingredient with sweet, floral, fruity odour. It is classified as a cosmetic ingredient in our database. CAS number: 6259-76-3.
What is the Margin of Safety for Hexyl Salicylate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Hexyl Salicylate?
The NOAEL (No Observed Adverse Effect Level) for Hexyl Salicylate is =75 mg/kg/day based on a developmental study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS.
Compliance Tools
Check Hexyl Salicylate compliance across multiple jurisdictions:
Related Ingredients
Is Hexyl Salicylate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Hexyl Salicylate in your formulation.