What is the NOAEL for Octadecanoic acid, 1,2-ethanediyl ester?
Octadecanoic acid, 1,2-ethanediyl ester has 6 NOAEL studies in the database. The lowest reported value is 13W7MDN21W UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Octadecanoic acid, 1,2-ethanediyl ester
Also known as: EINECS 211-014-3, 1,2-Ethanediyl bis(octadecanoate), Ethylene glycol, distearate, UNII-13W7MDN21W
CAS 627-83-8
Octadecanoic acid, 1,2-ethanediyl ester (CAS 627-83-8) is a chemical substance. Key regulatory status: REACH registered, 13 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
13
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
10 fields
Name
Octadecanoic acid, 1,2-ethanediyl ester
CAS Number
627-83-8
DTXSID
DTXSID6027260
Molecular Formula
C38H74O4
InChI Key
FPVVYTCTZKCSOJ-UHFFFAOYSA-N
Monoisotopic Mass
594.558711
Synonyms
EINECS 211-014-31,2-Ethanediyl bis(octadecanoate)Ethylene glycol, distearateUNII-13W7MDN21W
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
PigmentOpaciferSoftener and conditionerEmulsifierViscosity modifierHumectantThickening agentSurfactant (surface active agent)Lubricating agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
13 records
| List | Keyword | Source |
|---|---|---|
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - body hygiene - body wash | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bubble bath | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair styling and care - shampoo-dandruff | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair styling and care - shampoo-dandruff | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 13W7MDN21W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 13W7MDN21W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 13W7MDN21W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 13W7MDN21W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1000 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_HESS |
Showing 6 of 6 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Ethylene distearate | 211-014-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
emulsifier
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
GLYCOL DISTEARATE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include Octadecanoic acid, 1,2-ethanediyl ester?
Octadecanoic acid, 1,2-ethanediyl ester appears on 10 regulatory/inventory lists including food_additive; Substances Added to Food (formerly EAFUS) (2/2019), children; Europe; Personal care, children; Europe; Personal care - specialized bath products - bath salts, and 7 more. Source: EPA CPDat.
Is Octadecanoic acid, 1,2-ethanediyl ester used in cosmetics?
Yes, Octadecanoic acid, 1,2-ethanediyl ester is also indexed as a cosmetic ingredient under the name Glycol Distearate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Octadecanoic acid, 1,2-ethanediyl ester come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Octadecanoic acid, 1,2-ethanediyl ester used outside industrial chemicals?
Octadecanoic acid, 1,2-ethanediyl ester also appears in cosmetics, pharmaceutical, food safety databases.