Is Glycol Distearate safe in cosmetics?
Glycol Distearate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Emulsifier
Glycol Distearate
Also known as: EINECS 211-014-3, 1,2-Ethanediyl bis(octadecanoate), Ethylene glycol, distearate, UNII-13W7MDN21W
INCI: GLYCOL DISTEARATE
Glycol Distearate (CAS 627-83-8) is a cosmetic emulsifier functioning as Opacifying/pearlizing agent, emollient, emulsifier. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 627-83-8 →
Auto-generated CPSR Part A draft with source citations
Function
Opacifying/pearlizing agent, emollient, emulsifier
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-octadecanoyloxyethyl octadecanoate
InChIKey
FPVVYTCTZKCSOJ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR safe as used (1982, reaffirmed 2001). 1,613 VCRP formulations. Also permitted in food contact.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Glycol Distearate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
2 property records from structured ingredient metadata.
emulsion_hlb
{"hlb_required_as_emulsifier": "no", "hlb_required_of_oil_phase": "1", "co_emulsifier_pairs": "sorbitan_trioleate,glyceryl_stearate", "optimal_oil_phase_pct": "75-90", "optimal_water_phase_pct": "10-25", "droplet_size_range_um": "10-80", "creaming_resistance": "poor", "coalescence_resistance": "excellent", "ostwald_ripening_resistance": "excellent", "freeze_thaw_stability": "moderate", "rheology_m…
regulatory
{"eu_status": "allowed", "us_status": "allowed"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Emulsifier
Humectant
Lubricating agent
Opacifer
Pigment
Softener and conditioner
Surfactant (surface active agent)
Thickening agent
Viscosity modifier
Regulatory List Membership (4)
EU Regulated in Personal Care
EU Restricted for Children (Cosmetics)
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Glycol Distearate.
Regulatory Flags
eu_children_restricted
epa_safer_alternative
fda_food_additive
Known Synonyms
EINECS 211-014-3
1,2-Ethanediyl bis(octadecanoate)
Ethylene glycol, distearate
UNII-13W7MDN21W
Chemical Function
Pigment
Opacifer
Softener and conditioner
Emulsifier
Viscosity modifier
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
children; Europe; Personal care
children; Europe; Personal care - specialized bath products - bath salts
children; Europe; Personal care - body hygiene - body wash
children; Europe; Personal care - hair styling and care - shampoo
children; Europe; Personal care - specialized bath products - bubble bath
children; Europe; Personal care
Europe; Personal care - hair styling and care - shampoo-dandruff
Europe; Personal care - hair styling and care - shampoo-dandruff
Europe; Personal care
Europe; Personal care
SCIL (9/2019)
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
GLYCOL DISTEARATE
ChEMBL ID
CHEMBL2106683
Max Phase
-1
Frequently Asked Questions
Is Glycol Distearate allowed in the EU?
Glycol Distearate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Glycol Distearate do in cosmetics?
Glycol Distearate functions as: Opacifying/pearlizing agent, emollient, emulsifier. It is classified as a Emulsifier in our database. CAS number: 627-83-8.
Is Glycol Distearate used outside cosmetics?
Glycol Distearate also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Glycol Distearate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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