What is the NOAEL for Dimethyl adipate?
Dimethyl adipate has 7 NOAEL studies in the database. The lowest reported value is 8.3 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dimethyl adipate
Also known as: 1,6-Dimethyl hexanedioate, Dimethyladipate, 4-02-00-01959, Adipic acid dimethyl ester, BRN 1707443 (+3 more)
CAS 627-93-0
Dimethyl adipate (CAS 627-93-0) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
Dimethyl adipate
CAS Number
627-93-0
DTXSID
DTXSID8025096
Molecular Formula
C8H14O4
InChI Key
UDSFAEKRVUSQDD-UHFFFAOYSA-N
Monoisotopic Mass
174.089209
Synonyms
1,6-Dimethyl hexanedioateDimethyladipate4-02-00-01959Adipic acid dimethyl esterBRN 17074431,6-DimethylhexanedioateEINECS 211-020-6UNII-BY71RX0R62
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
SolventSoftener and conditionerPlasticizerFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| artificial_sweat; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| artificial_saliva; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =8.3 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| BY71RX0R62 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BY71RX0R62 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BY71RX0R62 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BY71RX0R62 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dimethyl adipate | 211-020-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1566491
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include Dimethyl adipate?
Dimethyl adipate appears on 7 regulatory/inventory lists including CEDI, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 4 more. Source: EPA CPDat.
Is Dimethyl adipate used in cosmetics?
Yes, Dimethyl adipate is also indexed as a cosmetic ingredient under the name Dimethyl Adipate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dimethyl adipate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Dimethyl adipate used outside industrial chemicals?
Dimethyl adipate also appears in cosmetics, pharmaceutical, food safety databases.