Is Dimethyl Adipate safe in cosmetics?
Dimethyl Adipate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Dimethyl Adipate
Also known as: 1,6-Dimethyl hexanedioate, Dimethyladipate, 4-02-00-01959, Adipic acid dimethyl ester, BRN 1707443 (+3 more)
INCI: DIMETHYL ADIPATE
Dimethyl Adipate (CAS 627-93-0) is a cosmetic cosmetic ingredient functioning as Solvent; fragrance ingredient; plasticizer. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 627-93-0 →
Auto-generated CPSR Part A draft with source citations
Function
Solvent; fragrance ingredient; plasticizer
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
dimethyl hexanedioate
InChIKey
UDSFAEKRVUSQDD-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS (flavoring); not prohibited under 21 CFR 700
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dimethyl Adipate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Regulatory (2)
JECFA Number
1964
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
DIMETHYL ADIPATE | 2010 | No safety concern at current levels of intake when used as a flavouring agent | TRS 960-JECFA 73/71
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Plasticizer
Softener and conditioner
Solubility enhancer
Solvent
Thickening agent
Regulatory List Membership (3)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Dimethyl Adipate.
Regulatory Flags
potential-allergen
fragrance-component
epa_safer_alternative
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
1,6-Dimethyl hexanedioate
Dimethyladipate
4-02-00-01959
Adipic acid dimethyl ester
BRN 1707443
1,6-Dimethylhexanedioate
EINECS 211-020-6
UNII-BY71RX0R62
Chemical Function
Solvent
Softener and conditioner
Plasticizer
Fragrance
Regulatory Lists
CEDI
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
artificial_sweat; detected; emissions; Europe; Other direct contact consumer goods
artificial_saliva; detected; emissions; Europe; Toys and children's products
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1566491
Frequently Asked Questions
Is Dimethyl Adipate allowed in the EU?
Dimethyl Adipate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethyl Adipate do in cosmetics?
Dimethyl Adipate functions as: Solvent; fragrance ingredient; plasticizer. It is classified as a cosmetic ingredient in our database. CAS number: 627-93-0.
Is Dimethyl Adipate used outside cosmetics?
Dimethyl Adipate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dimethyl Adipate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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