Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Dimethyl Adipate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | 1000 mg/kg bw/day | dermal | rat | dermal | REACH |
Expert Verdict
Not classified as hazardous per EC 1272/2008. LD50 oral rat >5,000 mg/kg. No skin irritation or eye irritation in rabbit tests. JECFA reports no safety concern at current levels of intake. Not phototoxic or photoallergenic.
Regulatory Flags
Frequently Asked Questions
Is Dimethyl Adipate safe in cosmetics?
Not classified as hazardous per EC 1272/2008. LD50 oral rat >5,000 mg/kg. No skin irritation or eye irritation in rabbit tests. JECFA reports no safety concern at current levels of intake. Not phototoxic or photoallergenic. The EU classifies Dimethyl Adipate as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.
Is Dimethyl Adipate allowed in the EU?
Dimethyl Adipate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethyl Adipate do in cosmetics?
Dimethyl Adipate functions as: Solvent; fragrance ingredient; plasticizer. It is classified as a cosmetic ingredient in our database. CAS number: 627-93-0.
What is the Margin of Safety for Dimethyl Adipate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dimethyl Adipate?
The NOAEL (No Observed Adverse Effect Level) for Dimethyl Adipate is 1000 mg/kg bw/day based on a dermal study via dermal route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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