What is the NOAEL for 1,6-Hexanediol?
1,6-Hexanediol has 10 NOAEL studies in the database. The lowest reported value is 35 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1,6-Hexanediol
Also known as: BRN 1633461, EINECS 211-074-0, UNII-ZIA319275I, 6-hydroxy-1-hexanol, alpha,omega-Hexanediol
CAS 629-11-8
1,6-Hexanediol (CAS 629-11-8) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
1,6-Hexanediol
CAS Number
629-11-8
DTXSID
DTXSID1027265
Molecular Formula
C6H14O2
InChI Key
XXMIOPMDWAUFGU-UHFFFAOYSA-N
Monoisotopic Mass
118.09938
Synonyms
BRN 1633461EINECS 211-074-0UNII-ZIA319275I6-hydroxy-1-hexanolalpha,omega-Hexanediol
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Solvent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =35 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| ZIA319275I | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ZIA319275I | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ZIA319275I | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ZIA319275I | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =3000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3730 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =400 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Hexane-1,6-diol | 211-074-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Solvents
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
1,6-HEXANEDIOL
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 1,6-Hexanediol?
1,6-Hexanediol appears on 1 regulatory/inventory list including Indirect additives food contact (10/2018). Source: EPA CPDat.
Is 1,6-Hexanediol used in cosmetics?
Yes, 1,6-Hexanediol is also indexed as a cosmetic ingredient under the name HEXANEDIOL. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1,6-Hexanediol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 1,6-Hexanediol used outside industrial chemicals?
1,6-Hexanediol also appears in cosmetics, pharmaceutical databases.