Is HEXANEDIOL safe in cosmetics?
HEXANEDIOL has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
HEXANEDIOL
Also known as: BRN 1633461, EINECS 211-074-0, UNII-ZIA319275I, 6-hydroxy-1-hexanol, alpha,omega-Hexanediol
HEXANEDIOL (CAS 629-11-8) is a cosmetic cosmetic ingredient functioning as Solvent. Reported NOAEL =400 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 629-11-8 →
Auto-generated CPSR Part A draft with source citations
Chemistry & Identifiers
IUPAC Name
hexane-1,6-diol
InChIKey
XXMIOPMDWAUFGU-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR: S - Final Report 9/2017 Available from CIR
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
2 study endpoints found for HEXANEDIOL. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =400 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
preservative
{"preservative_class": "Glycol", "antimicrobial_spectrum_bacteria_gp": "Moderate", "antimicrobial_spectrum_bacteria_gn": "Moderate", "antimicrobial_spectrum_yeast": "Moderate", "antimicrobial_spectrum_mold": "Moderate", "mic_staph_aureus_ppm": "3500", "mic_e_coli_ppm": "3500", "mic_pseudomonas_ppm": "3500", "mic_candida_albicans_ppm": "3500", "mic_aspergillus_niger_ppm": "3500", "challenge_test_pa…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
0491
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Solvent
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for HEXANEDIOL.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to HEXANEDIOL by CAS number or substance name.
Studies
2
Lowest NOAEL
400 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
BRN 1633461
EINECS 211-074-0
UNII-ZIA319275I
6-hydroxy-1-hexanol
alpha,omega-Hexanediol
Chemical Function
Solvent
Regulatory Lists
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
1,6-HEXANEDIOL
ChEMBL ID
CHEMBL458616
Frequently Asked Questions
Is HEXANEDIOL allowed in the EU?
HEXANEDIOL EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does HEXANEDIOL do in cosmetics?
HEXANEDIOL functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 629-11-8.
What is the NOAEL for HEXANEDIOL?
The NOAEL (No Observed Adverse Effect Level) for HEXANEDIOL is =400 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is HEXANEDIOL used outside cosmetics?
HEXANEDIOL also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check HEXANEDIOL compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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