What is the NOAEL for L-Phenylalanine?
L-Phenylalanine has 13 NOAEL studies in the database. The lowest reported value is 47E5O17Y3R UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
L-Phenylalanine
Also known as: Phenylalanine (ENCS), Alanine, 3-phenyl-, alpha-Aminohydrocinnamic acid, L-, alpha-Amino-beta-phenylpropionic acid, L-, 2-Amino-3-phenylpropionic acid, L- (+15 more)
CAS 63-91-2
L-Phenylalanine (CAS 63-91-2) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
L-Phenylalanine
CAS Number
63-91-2
DTXSID
DTXSID4040763
Molecular Formula
C9H11NO2
InChI Key
COLNVLDHVKWLRT-QMMMGPOBSA-N
Monoisotopic Mass
165.078979
Synonyms
Phenylalanine (ENCS)Alanine, 3-phenyl-alpha-Aminohydrocinnamic acid, L-alpha-Amino-beta-phenylpropionic acid, L-2-Amino-3-phenylpropionic acid, L-L-Antibiotic FN 1636EINECS 200-568-1FEMA No. 3585Hydrocinnamic acid, alpha-amino-beta-Phenylalnine, (-)-FenilalaninaPhenylalaninum
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
Flavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | US International Trade Commission | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 47E5O17Y3R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 47E5O17Y3R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 47E5O17Y3R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 47E5O17Y3R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 450 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 820 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS_DB |
| 1300 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 5000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 7000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| ~500 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| ~1500 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3-phenyl-L-alanine | 200-568-1 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Amino Acid
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
PHENYLALANINE
ChEMBL Phase
3
Adverse Events
7
Bioactivity
12
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include L-Phenylalanine?
L-Phenylalanine appears on 3 regulatory/inventory lists including Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), pharmaceutical. Source: EPA CPDat.
Is L-Phenylalanine used in cosmetics?
Yes, L-Phenylalanine is also indexed as a cosmetic ingredient under the name L-Phenylalanine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for L-Phenylalanine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is L-Phenylalanine used outside industrial chemicals?
L-Phenylalanine also appears in cosmetics, pharmaceutical, cannabis databases.