Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for L-Phenylalanine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 7000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 450 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
| NOAEL | 1500 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| NOAEL | 1300 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| NOAEL | 820 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| dose_tested | 450 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
| NOEL | ca.500 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Essential aromatic amino acid functioning as fragrance enhancer, hair conditioner, and masking agent in cosmetics; safe for topical application with minimal dermal absorption and low sensitization potential.
Regulatory Flags
Frequently Asked Questions
Is L-Phenylalanine safe in cosmetics?
Essential aromatic amino acid functioning as fragrance enhancer, hair conditioner, and masking agent in cosmetics; safe for topical application with minimal dermal absorption and low sensitization potential. The EU classifies L-Phenylalanine as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is L-Phenylalanine allowed in the EU?
L-Phenylalanine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does L-Phenylalanine do in cosmetics?
L-Phenylalanine functions as: Fragrance, Hair conditioning, Masking. It is classified as a cosmetic ingredient in our database. CAS number: 63-91-2.
What is the Margin of Safety for L-Phenylalanine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for L-Phenylalanine?
The NOAEL (No Observed Adverse Effect Level) for L-Phenylalanine is 5000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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