What is the NOAEL for 2-Amino-6-chloro-4-nitrophenol?
2-Amino-6-chloro-4-nitrophenol has 41 NOAEL studies in the database. The lowest reported value is 2.2 % via Dermal in Mouse. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Amino-6-chloro-4-nitrophenol
Also known as: EINECS 228-762-1, UNII-0ZLP5I1TMC
CAS 6358-09-4
2-Amino-6-chloro-4-nitrophenol (CAS 6358-09-4) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
View cosmetic safety profile for 2-Amino-6-Chloro-4-Nitrophenol →
Cross-Vertical Regulatory Divergence
2-Amino-6-chloro-4-nitrophenol is prohibited in EU cosmetics at max 2.0% but has active industrial GHS classifications (H315, H317, H319, H335, H411).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
41
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
8 fields
Name
2-Amino-6-chloro-4-nitrophenol
CAS Number
6358-09-4
DTXSID
DTXSID9043855
Molecular Formula
C6H5ClN2O3
InChI Key
TWLMSPNQBKSXOP-UHFFFAOYSA-N
Monoisotopic Mass
187.99887
Synonyms
EINECS 228-762-1UNII-0ZLP5I1TMC
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care; restricted | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 41 of 41 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 2.2 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 6.85 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 0ZLP5I1TMC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0ZLP5I1TMC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0ZLP5I1TMC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0ZLP5I1TMC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 10 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| ~90 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =0.065 | mg/kg | NOAEL | dermal | human | SCCS_vision_codex |
| =0.065 | mg/kg | NOAEL | dermal | human | SCCS_vision_codex |
| =0.065 | mg/kg | NOAEL | dermal | human | SCCS_vision_codex |
| =0.065 | mg/kg | NOAEL | dermal | human | SCCS_vision_codex |
| ~30 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =30 | mg / kg / day | NOAEL | oral | rat | CIR_vision_codex |
| =30 | mg/kg bw | NOAEL | - | human | SCCS_vision_codex |
| =30 | mg/kg | NOAEL | dermal | human | SCCS_vision_codex |
| =30 | mg / kg / day | NOAEL | oral | rat | CIR_vision_codex |
| =30 | mg / kg / day | NOAEL | oral | rat | CIR_vision_codex |
| =30 | mg/kg bw | NOAEL | - | human | SCCS_vision_codex |
| =30 | mg/kg | NOAEL | dermal | human | SCCS_vision_codex |
| =30 | mg/kg bw | NOAEL | - | human | SCCS_vision_codex |
| =30 | mg/kg | NOAEL | dermal | human | SCCS_vision_codex |
| =30 | mg / kg / day | NOAEL | oral | rat | CIR_vision_codex |
| =30 | mg/kg bw | NOAEL | - | human | SCCS_vision_codex |
| =30 | mg/kg | NOAEL | dermal | human | SCCS_vision_codex |
| =90 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =90 | mg/kg bw | NOAEL | - | human | SCCS_vision_codex |
| =90 | mg/kg bw | NOAEL | - | human | SCCS_vision_codex |
| =90 | mg/kg bw | NOAEL | - | human | SCCS_vision_codex |
| =90 | mg/kg bw | NOAEL | - | human | SCCS_vision_codex |
| =2000 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =2000 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =2000 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =2000 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =0.065 | mg/kg | dermal absorption | dermal | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =30 | mg/kg | dermal absorption | dermal | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =30 | mg/kg | dermal absorption | dermal | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 30 | mg/kg bw | developmental toxicity | - | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 90 | mg/kg bw | developmental toxicity | - | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 30 | mg / kg / day | repeated dose toxicity | oral | rat | UnifiedCodex:CIR:beta.noael_studies |
| 2000 | mg/kg bw | repeated dose toxicity | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
Showing 41 of 41 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-amino-6-chloro-4-nitrophenol | 228-762-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCP/0922/05 | 28 March 2006 | safe | 2.0% | secondary amine; nitrosamine <50ppb; sensitisation not excluded |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
2.0%
Category
Colorant
Frequently Asked Questions
What regulatory lists include 2-Amino-6-chloro-4-nitrophenol?
2-Amino-6-chloro-4-nitrophenol appears on 2 regulatory/inventory lists including Europe; Personal care - hair coloring, Europe; Personal care; restricted. Source: EPA CPDat.
Is 2-Amino-6-chloro-4-nitrophenol used in cosmetics?
Yes, 2-Amino-6-chloro-4-nitrophenol is also indexed as a cosmetic ingredient under the name 2-Amino-6-Chloro-4-Nitrophenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Amino-6-chloro-4-nitrophenol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Amino-6-chloro-4-nitrophenol have different safety status in cosmetics vs industrial chemicals?
2-Amino-6-chloro-4-nitrophenol is prohibited in EU cosmetics at max 2.0% but has active industrial GHS classifications (H315, H317, H319, H335, H411).
Is 2-Amino-6-chloro-4-nitrophenol used outside industrial chemicals?
2-Amino-6-chloro-4-nitrophenol also appears in cosmetics databases.