2-Amino-6-Chloro-4-Nitrophenol
INCI: 2-AMINO-6-CHLORO-4-NITROPHENOL
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for 2-Amino-6-Chloro-4-Nitrophenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 10 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | ca.30 mg/kg bw/day | oral | rat | oral | REACH |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Sensitization Profile
Contact sensitization data for 2-Amino-6-Chloro-4-Nitrophenol based on clinical patch test studies and IFRA standards.
Source: IVDK; NACDG; ESSCA
Expert Verdict
CLP hazards: H315 (skin irritant Cat 2), H317 (skin sensitiser Cat 1A), H319 (eye irritant Cat 2). Mandatory patch test warning on label. The CIR Panel reaffirmed safety in 2012 but noted no basis for changing consumer patch-test advice.
Regulatory Flags
Frequently Asked Questions
Is 2-Amino-6-Chloro-4-Nitrophenol safe in cosmetics?
CLP hazards: H315 (skin irritant Cat 2), H317 (skin sensitiser Cat 1A), H319 (eye irritant Cat 2). Mandatory patch test warning on label. The CIR Panel reaffirmed safety in 2012 but noted no basis for changing consumer patch-test advice. The EU classifies 2-Amino-6-Chloro-4-Nitrophenol as "prohibited". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Is 2-Amino-6-Chloro-4-Nitrophenol allowed in the EU?
2-Amino-6-Chloro-4-Nitrophenol EU regulatory status: prohibited. Maximum allowed concentration: 2.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Amino-6-Chloro-4-Nitrophenol do in cosmetics?
2-Amino-6-Chloro-4-Nitrophenol functions as: Hair dyeing (semi-permanent and oxidative). It is classified as a cosmetic ingredient in our database. CAS number: 6358-09-4.
What is the Margin of Safety for 2-Amino-6-Chloro-4-Nitrophenol?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 2-Amino-6-Chloro-4-Nitrophenol?
The NOAEL (No Observed Adverse Effect Level) for 2-Amino-6-Chloro-4-Nitrophenol is 10 mg/kg bw/day based on a Developmental study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check 2-Amino-6-Chloro-4-Nitrophenol compliance across multiple jurisdictions:
Related Ingredients
Is 2-Amino-6-Chloro-4-Nitrophenol in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 2-Amino-6-Chloro-4-Nitrophenol in your formulation.