Also known as: EINECS 228-762-1, UNII-0ZLP5I1TMC
INCI: 2-AMINO-6-CHLORO-4-NITROPHENOL
2-Amino-6-Chloro-4-Nitrophenol (CAS 6358-09-4) is a cosmetic cosmetic ingredient functioning as Hair dyeing (semi-permanent and oxidative). NOAEL 30 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited, max 2.0%; 2 safety opinions reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 6358-09-4 →
2-Amino-6-Chloro-4-Nitrophenol is prohibited in EU cosmetics at max 2.0% but has active industrial GHS classifications (H315, H317, H319, H335, H411).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Amino-6-Chloro-4-Nitrophenol.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for 2-Amino-6-Chloro-4-Nitrophenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.065 mg/kg | dermal | human | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.065 mg/kg | dermal | human | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.065 mg/kg | dermal | human | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.065 mg/kg | dermal | human | dermal absorption | SCCS_vision_codex |
| NOAEL | =30 mg/kg bw | - | human | developmental toxicity | SCCS_vision_codex |
| NOAEL | =30 mg/kg | dermal | human | dermal absorption | SCCS_vision_codex |
| NOAEL | =30 mg/kg bw | - | human | developmental toxicity | SCCS_vision_codex |
| NOAEL | =30 mg/kg | dermal | human | dermal absorption | SCCS_vision_codex |
| NOAEL | =30 mg/kg bw | - | human | developmental toxicity | SCCS_vision_codex |
| NOAEL | =30 mg/kg | dermal | human | dermal absorption | SCCS_vision_codex |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Pre-calculated NOAEL → SED → MoS audit trail for 2-Amino-6-Chloro-4-Nitrophenol across SCCS product categories, with measured dermal absorption where available.
Contact sensitization data for 2-Amino-6-Chloro-4-Nitrophenol based on clinical patch test studies and IFRA standards.
Source: IVDK; NACDG; ESSCA
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
Source: LLNA: CosmEur database; KS: Cosmetics Europe; hCLAT: Cosmetics Europe
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 0.248% | - | - | SCCP/0948/05 |
2 property records from structured ingredient metadata.
Expert safety assessment and concern-level summary for 2-Amino-6-Chloro-4-Nitrophenol.
Public NOAEL study rows linked to 2-Amino-6-Chloro-4-Nitrophenol by CAS number or substance name.
Units vary across source rows: mg/kg bw/day, mg/kg bw, mg/kg
| Absorption % | Method | Vehicle |
|---|---|---|
| 0.248% | SCCS opinion extraction | - |
2-Amino-6-Chloro-4-Nitrophenol has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
2-Amino-6-Chloro-4-Nitrophenol EU regulatory status: prohibited. Maximum allowed concentration: 2.0%. This is based on EU Regulation 1223/2009 and its amendments.
2-Amino-6-Chloro-4-Nitrophenol functions as: Hair dyeing (semi-permanent and oxidative). It is classified as a cosmetic ingredient in our database. CAS number: 6358-09-4.
The NOAEL (No Observed Adverse Effect Level) for 2-Amino-6-Chloro-4-Nitrophenol is =0.065 mg/kg based on a dermal absorption study via dermal route in human. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
2-Amino-6-Chloro-4-Nitrophenol also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
2-Amino-6-Chloro-4-Nitrophenol is prohibited in EU cosmetics at max 2.0% but has active industrial GHS classifications (H315, H317, H319, H335, H411).
Check 2-Amino-6-Chloro-4-Nitrophenol compliance across multiple jurisdictions:
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