What is the NOAEL for C.I. Pigment Yellow 12?
C.I. Pigment Yellow 12 has 20 NOAEL studies in the database. The lowest reported value is N52TUS5TRY UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
C.I. Pigment Yellow 12
Also known as: Pigment yellow 12, 2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[3-oxo-N-phenylbutanamide], Butanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[3-oxo-N-phenyl-, Butanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[3-oxo-N-phenyl-, Acetoacetanilide, 2,2''-(3,3'-dichloro-4,4'-biphenylylenebisazo)bis (+15 more)
CAS 6358-85-6
C.I. Pigment Yellow 12 (CAS 6358-85-6) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
20
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
C.I. Pigment Yellow 12
CAS Number
6358-85-6
DTXSID
DTXSID1021451
Molecular Formula
C32H26Cl2N6O4
InChI Key
GNCOVOVCHIHPHP-UHFFFAOYSA-N
Monoisotopic Mass
628.139259
Synonyms
Pigment yellow 122,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[3-oxo-N-phenylbutanamide]Butanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[3-oxo-N-phenyl-Butanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[3-oxo-N-phenyl-Acetoacetanilide, 2,2''-(3,3'-dichloro-4,4'-biphenylylenebisazo)bis2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[3-oxo-N-phenylbutanamideAmazon Yellow X 2485Benzidine YellowBenzidine Yellow 12Benzidine Yellow 1316Benzidine Yellow AAABenzidine Yellow HG-Plv
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
16 records
DyePigment
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 20 of 20 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| N52TUS5TRY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N52TUS5TRY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N52TUS5TRY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N52TUS5TRY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >0.23 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >4.25 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2228 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >2350 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >2850 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >10000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >10800 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >15000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =702 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1665 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =2500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =3900 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =9250 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| 5 | % | Top dose | - | Rat | NTP_ICE_cancer |
Showing 20 of 20 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[3-oxo-N-phenylbutyramide] | 228-787-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Colorant
Frequently Asked Questions
What regulatory lists include C.I. Pigment Yellow 12?
C.I. Pigment Yellow 12 appears on 3 regulatory/inventory lists including banned; Europe; Personal care, Europe; plastic_additive, Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe. Source: EPA CPDat.
Is C.I. Pigment Yellow 12 used in cosmetics?
Yes, C.I. Pigment Yellow 12 is also indexed as a cosmetic ingredient under the name Pigment Yellow 12. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for C.I. Pigment Yellow 12 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is C.I. Pigment Yellow 12 used outside industrial chemicals?
C.I. Pigment Yellow 12 also appears in cosmetics databases.