Is Pigment Yellow 12 safe in cosmetics?
Pigment Yellow 12 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: prohibited. 5 toxicological study endpoint(s) are available in our database.
Pigment Yellow 12
Also known as: 2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[3-oxo-N-phenylbutanamide], Butanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[3-oxo-N-phenyl-, Butanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[3-oxo-N-phenyl-, Acetoacetanilide, 2,2''-(3,3'-dichloro-4,4'-biphenylylenebisazo)bis, 2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[3-oxo-N-phenylbutanamide (+14 more)
INCI: PIGMENT YELLOW 12
Pigment Yellow 12 (CAS 6358-85-6) is a cosmetic cosmetic ingredient functioning as Colorant. Reported NOAEL =702 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 6358-85-6 →
Auto-generated CPSR Part A draft with source citations
Function
Colorant
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-[[4-[4-[(1-anilino-1,3-dioxobutan-2-yl)diazenyl]-3-chlorophenyl]-2-chlorophenyl]diazenyl]-3-oxo-N-phenylbutanamide
InChIKey
GNCOVOVCHIHPHP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
prohibited
US Notes
Not FDA-listed for cosmetic use — unlawful for US cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Pigment Yellow 12.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Pigment Yellow 12. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =702 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =1665 mg/kg bw/day | oral | Mouse | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =2500 mg/kg bw/day | oral | Rat | repeat dose other | ToxValDB_ECHA_IUCLID |
| NOAEL | =3900 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =9250 mg/kg bw/day | oral | Mouse | chronic | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1263
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1263
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
Diarylanilide yellow | TR-030: Bioassay of Diarylanilide Yellow for Possible Carcinogenicity (CASRN 6358-85-6) (1978 ) | 09/26/77 | No Evidence | No Evidence | No Evidence | No Evidence
Source: NTP Technical Reports
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Pigment
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Pigment Yellow 12.
Regulatory Flags
colorant
eu_banned_cosmetics
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Pigment Yellow 12 by CAS number or substance name.
Studies
5
Lowest NOAEL
702 mg/kg bw/day
Highest NOAEL
9250 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[3-oxo-N-phenylbutanamide]
Butanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[3-oxo-N-phenyl-
Butanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[3-oxo-N-phenyl-
Acetoacetanilide, 2,2''-(3,3'-dichloro-4,4'-biphenylylenebisazo)bis
2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[3-oxo-N-phenylbutanamide
Amazon Yellow X 2485
Benzidine Yellow
Benzidine Yellow 12
Benzidine Yellow 1316
Benzidine Yellow AAA
Benzidine Yellow HG-Plv
Benzidine Yellow Toner YA 8081
Benzidine Yellow Toner YT 378
Benzyl Yellow G
C.I. 21090
Diarylide Yellow AAMX
Disazo Yellow
Helio Yellow GW
Japan Yellow 205
Chemical Function
Dye
Pigment
Regulatory Lists
banned; Europe; Personal care
Europe; plastic_additive
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Pigment Yellow 12 allowed in the EU?
Pigment Yellow 12 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Pigment Yellow 12 do in cosmetics?
Pigment Yellow 12 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 6358-85-6.
What is the NOAEL for Pigment Yellow 12?
The NOAEL (No Observed Adverse Effect Level) for Pigment Yellow 12 is =702 mg/kg bw/day based on a chronic study via oral route in Rat. A total of 5 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Pigment Yellow 12 used outside cosmetics?
Pigment Yellow 12 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Pigment Yellow 12 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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