NOAEL Data Cosmetic Ingredient

4-((2-Hydroxyethyl)amino)-3-nitrophenol

Also known as: EINECS 265-648-0, UNII-AIP2J155AN

CAS 65235-31-6

4-((2-Hydroxyethyl)amino)-3-nitrophenol (CAS 65235-31-6) is a chemical substance. Key regulatory status: 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS.

View cosmetic safety profile for 3-Nitro-P-Hydroxyethylaminophenol →

Cross-Vertical Regulatory Divergence

4-((2-Hydroxyethyl)amino)-3-nitrophenol is prohibited in EU cosmetics at max 3.0% but has active industrial GHS classifications (H317, H361d, H302, H315, H319, H335, H411).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 7 fields

Name

4-((2-Hydroxyethyl)amino)-3-nitrophenol

CAS Number

65235-31-6

Molecular Formula

C8H10N2O4

InChI Key

UXKLYBMQAHYULT-UHFFFAOYSA-N

Monoisotopic Mass

198.064057

Synonyms

EINECS 265-648-0UNII-AIP2J155AN

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records

List	Keyword	Source
Canada; Personal care; Substances in PCP - Canada (4/2014)	Government of Canada	CPCat
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care; restricted	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 17 of 17 studies

Value	Unit	Endpoint	Route	Species	Source
15	%	-	-	-	Regulatory source
200	mg/kg bw/day	-	-	rat	Regulatory source
1000	mg/kg/day	-	oral	rat	Regulatory source
0.1	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
AIP2J155AN	UNII	FDA UNII substance identifier	-	-	openFDA substances
100	mg/kg bw/day	LOAEL	oral	rat	COSMOS DB
=15	%	NOAEL	-	-	SCCS Opinion
=100	mg/kg/day	NOAEL	-	rat	SCCS Opinion
=100	mg/kg	NOAEL	oral	rat	SCCS Opinion
=200	mg/kg bw/day	NOAEL	-	rat	SCCS Opinion
=1000	mg/kg/day	NOAEL	oral	rat	SCCS Opinion
=1000	mg/kg	NOAEL	-	rat	SCCS Opinion
100	mg/kg/day	developmental toxicity	-	rat	Regulatory source
100	mg/kg/day	developmental toxicity	-	human	Regulatory source
=100	mg/kg	developmental toxicity	oral	rat	Regulatory source
100	mg/kg/day	developmental toxicity	dermal	rabbit	Regulatory source
1000	mg/kg	developmental toxicity	-	rat	Regulatory source

Showing 17 of 17 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCP/1036/06	2006-12-19	Based on the information provided, the SCCP is of the opinion that the use of 3-nitro-p-hydroxyethylaminophenol itself as an oxidative hair dye substance at a maximum concentration of 3.0% in the finished cosmetic product (after mixing with hydrogen peroxide) or as an ingredient in semi-permanent hair colouring products at a maximum concentration of 1.85% does not pose a risk to the health of the consumer, apart from its sensitising potential.	3.0% (oxidative, after mixing with H2O2); 1.85% (semi-permanent)	Sensitising potential (extreme sensitiser in murine LLNA); secondary amine prone to nitrosation; must not be combined with nitrosating substances; nitrosamine content < 50 ppb.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

3.0%

Frequently Asked Questions

What is the NOAEL for 4-((2-Hydroxyethyl)amino)-3-nitrophenol?

4-((2-Hydroxyethyl)amino)-3-nitrophenol has 17 NOAEL studies in the database. The lowest reported value is 0.1 % via Dermal in Mouse. Source: NTP ICE skin sensitization.

What regulatory lists include 4-((2-Hydroxyethyl)amino)-3-nitrophenol?

4-((2-Hydroxyethyl)amino)-3-nitrophenol appears on 4 regulatory/inventory lists including Canada; Personal care; Substances in PCP - Canada (4/2014), Europe; Personal care - hair coloring, children; Europe; Personal care, and 1 more. Source: EPA CPDat.

Is 4-((2-Hydroxyethyl)amino)-3-nitrophenol used in cosmetics?

Yes, 4-((2-Hydroxyethyl)amino)-3-nitrophenol is also indexed as a cosmetic ingredient under the name 3-Nitro-P-Hydroxyethylaminophenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 4-((2-Hydroxyethyl)amino)-3-nitrophenol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 4-((2-Hydroxyethyl)amino)-3-nitrophenol have different safety status in cosmetics vs industrial chemicals?

4-((2-Hydroxyethyl)amino)-3-nitrophenol is prohibited in EU cosmetics at max 3.0% but has active industrial GHS classifications (H317, H361d, H302, H315, H319, H335, H411).

Is 4-((2-Hydroxyethyl)amino)-3-nitrophenol used outside industrial chemicals?

4-((2-Hydroxyethyl)amino)-3-nitrophenol also appears in cosmetics databases.