Moderate Cosmetic Ingredient NOAEL Data Sensitization Data

3-Nitro-P-Hydroxyethylaminophenol

CAS Number
65235-31-6
Function
Dye
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
EU Max Conc. 3.0%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted under FDA coal-tar hair dye exemption (FD&C Act ยง601(a)); no specific concentration limit in US regulations

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for 3-Nitro-P-Hydroxyethylaminophenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 100 mg/kg bw/day oral rat Developmental COSMOS_DB

Sensitization Profile

Contact sensitization data for 3-Nitro-P-Hydroxyethylaminophenol based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.2%
Cross-reactivity Group
para-amino-group
Reaction Type
contact-dermatitis

Source: IVDK; NACDG; ESSCA

Expert Verdict

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Concern Level: Moderate

Regulatory Flags

eu_children_restricted eu_cosing_listed

Frequently Asked Questions

Is 3-Nitro-P-Hydroxyethylaminophenol safe in cosmetics?

3-Nitro-P-Hydroxyethylaminophenol has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 1 toxicological study endpoint(s) are available in our database.

Is 3-Nitro-P-Hydroxyethylaminophenol allowed in the EU?

3-Nitro-P-Hydroxyethylaminophenol EU regulatory status: prohibited. Maximum allowed concentration: 3.0%. This is based on EU Regulation 1223/2009 and its amendments.

What does 3-Nitro-P-Hydroxyethylaminophenol do in cosmetics?

3-Nitro-P-Hydroxyethylaminophenol functions as: Dye. It is classified as a cosmetic ingredient in our database. CAS number: 65235-31-6.

What is the Margin of Safety for 3-Nitro-P-Hydroxyethylaminophenol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 3-Nitro-P-Hydroxyethylaminophenol?

The NOAEL (No Observed Adverse Effect Level) for 3-Nitro-P-Hydroxyethylaminophenol is 100 mg/kg bw/day based on a Developmental study via oral route in rat. Source: COSMOS_DB.

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