3-Nitro-P-Hydroxyethylaminophenol (CAS 65235-31-6) is a cosmetic cosmetic ingredient functioning as Dye. Reported NOAEL =100 mg/kg/day in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: prohibited, max 3.0%. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 65235-31-6 →
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for 3-Nitro-P-Hydroxyethylaminophenol.
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10 study endpoints found for 3-Nitro-P-Hydroxyethylaminophenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =100 mg/kg/day | - | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =100 mg/kg | oral | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =100 mg/kg/day | - | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =100 mg/kg | oral | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =100 mg/kg/day | - | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =100 mg/kg | oral | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =100 mg/kg/day | - | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =100 mg/kg | oral | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =200 mg/kg bw/day | - | rat | NOAEL study | SCCS_vision_codex |
| NOAEL | =200 mg/kg bw/day | - | rat | NOAEL study | SCCS_vision_codex |
Contact sensitization data for 3-Nitro-P-Hydroxyethylaminophenol based on clinical patch test studies and IFRA standards.
Source: IVDK; NACDG; ESSCA
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
2 property records from structured ingredient metadata.
Expert safety assessment and concern-level summary for 3-Nitro-P-Hydroxyethylaminophenol.
Public NOAEL study rows linked to 3-Nitro-P-Hydroxyethylaminophenol by CAS number or substance name.
Units vary across source rows: mg/kg/day, mg/kg, mg/kg bw/day
3-Nitro-P-Hydroxyethylaminophenol has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
3-Nitro-P-Hydroxyethylaminophenol EU regulatory status: prohibited. Maximum allowed concentration: 3.0%. This is based on EU Regulation 1223/2009 and its amendments.
3-Nitro-P-Hydroxyethylaminophenol functions as: Dye. It is classified as a cosmetic ingredient in our database. CAS number: 65235-31-6.
The NOAEL (No Observed Adverse Effect Level) for 3-Nitro-P-Hydroxyethylaminophenol is =100 mg/kg/day based on a developmental toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
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