What is the NOAEL for (3Z)-Hex-3-en-1-yl salicylate?
(3Z)-Hex-3-en-1-yl salicylate has 12 NOAEL studies in the database. The lowest reported value is 1.59 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
(3Z)-Hex-3-en-1-yl salicylate
Also known as: cis-3-hexenylsalicylate, Benzoic acid, 2-hydroxy-, (3Z)-3-hexen-1-yl ester, Benzoic acid, 2-hydroxy-, (3Z)-3-hexenyl ester, Benzoic acid, 2-hydroxy-, 3-hexenyl ester, (Z)-, Salicylic acid, 3-hexen-1-yl ester (+8 more)
CAS 65405-77-8
(3Z)-Hex-3-en-1-yl salicylate (CAS 65405-77-8) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
(3Z)-Hex-3-en-1-yl salicylate
CAS Number
65405-77-8
DTXSID
DTXSID8037750
Molecular Formula
C13H16O3
InChI Key
IEPWIPZLLIOZLU-ARJAWSKDSA-N
Monoisotopic Mass
220.109944
Synonyms
cis-3-hexenylsalicylateBenzoic acid, 2-hydroxy-, (3Z)-3-hexen-1-yl esterBenzoic acid, 2-hydroxy-, (3Z)-3-hexenyl esterBenzoic acid, 2-hydroxy-, 3-hexenyl ester, (Z)-Salicylic acid, 3-hexen-1-yl ester2-Hydroxybenzoic acid, (Z)-3-hexenyl ester(Z)-3-Hexenyl salicylateEINECS 265-745-8beta,gamma-cis-Hexenyl salicylatecis-3-Hexenyl salicylateUNII-C78Y9OR6YHSID26757650
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
| Europe | European Commission | Fl@vis |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1.59 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| C78Y9OR6YH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C78Y9OR6YH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C78Y9OR6YH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C78Y9OR6YH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2025 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =120 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HESS |
| =200 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =50 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | (Z)-3-hexenyl salicylate | 265-745-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include (3Z)-Hex-3-en-1-yl salicylate?
(3Z)-Hex-3-en-1-yl salicylate appears on 4 regulatory/inventory lists including SCIL (9/2019), IFRA Transparency, consumer_product, and 1 more. Source: EPA CPDat.
Is (3Z)-Hex-3-en-1-yl salicylate used in cosmetics?
Yes, (3Z)-Hex-3-en-1-yl salicylate is also indexed as a cosmetic ingredient under the name cis-3-Hexenyl Salicylate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for (3Z)-Hex-3-en-1-yl salicylate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is (3Z)-Hex-3-en-1-yl salicylate used outside industrial chemicals?
(3Z)-Hex-3-en-1-yl salicylate also appears in cosmetics, cannabis databases.