Moderate Cosmetic Ingredient Sensitization Data

cis-3-Hexenyl Salicylate

INCI: CIS-3-HEXENYL SALICYLATE

CAS Number
65405-77-8
Function
Fragrance ingredient with green, herbal, slightly medicinal profile
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes FEMA 4750; no CIR monograph; RIFM-assessed

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for cis-3-Hexenyl Salicylate based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.2%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
IFRA Restricted

Source: EU 2023/1545; SCCS

Expert Verdict

Suspected of damaging fertility or unborn child (Category 2); skin sensitizer with NESIL; IFRA restricts maximum use levels per application category

⚠️
Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component epa_safer_alternative ifra_fragrance jecfa_safe

Frequently Asked Questions

Is cis-3-Hexenyl Salicylate safe in cosmetics?

Suspected of damaging fertility or unborn child (Category 2); skin sensitizer with NESIL; IFRA restricts maximum use levels per application category The EU classifies cis-3-Hexenyl Salicylate as "permitted". Safety rating: MODERATE.

Is cis-3-Hexenyl Salicylate allowed in the EU?

cis-3-Hexenyl Salicylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does cis-3-Hexenyl Salicylate do in cosmetics?

cis-3-Hexenyl Salicylate functions as: Fragrance ingredient with green, herbal, slightly medicinal profile. It is classified as a cosmetic ingredient in our database. CAS number: 65405-77-8.

What is the Margin of Safety for cis-3-Hexenyl Salicylate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check cis-3-Hexenyl Salicylate compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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