Is cis-3-Hexenyl Salicylate safe in cosmetics?
cis-3-Hexenyl Salicylate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
cis-3-Hexenyl Salicylate
Also known as: cis-3-hexenylsalicylate, Benzoic acid, 2-hydroxy-, (3Z)-3-hexen-1-yl ester, Benzoic acid, 2-hydroxy-, (3Z)-3-hexenyl ester, Benzoic acid, 2-hydroxy-, 3-hexenyl ester, (Z)-, Salicylic acid, 3-hexen-1-yl ester (+7 more)
INCI: CIS-3-HEXENYL SALICYLATE
cis-3-Hexenyl Salicylate (CAS 65405-77-8) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient with green, herbal, slightly medicinal profile. Reported NOAEL =200 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 65405-77-8 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient with green, herbal, slightly medicinal profile
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
[(E)-hex-3-enyl] 2-hydroxybenzoate
InChIKey
IEPWIPZLLIOZLU-ONEGZZNKSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FEMA 4750; no CIR monograph; RIFM-assessed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for cis-3-Hexenyl Salicylate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for cis-3-Hexenyl Salicylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =200 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Sensitization Profile
Contact sensitization data for cis-3-Hexenyl Salicylate based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.2%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
IFRA Restricted
Source: EU 2023/1545; SCCS
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2025 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "yes", "allergen_class": "fragrance", "patch_test_frequency_pct": "0.2", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "yes", "source": "EU 2023/1545; SCCS"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (1)
JECFA Number
2275
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for cis-3-Hexenyl Salicylate.
Regulatory Flags
potential-allergen
fragrance-component
epa_safer_alternative
ifra_fragrance
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to cis-3-Hexenyl Salicylate by CAS number or substance name.
Studies
1
Lowest NOAEL
200 mg/kg bw/day
Highest NOAEL
200 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
cis-3-hexenylsalicylate
Benzoic acid, 2-hydroxy-, (3Z)-3-hexen-1-yl ester
Benzoic acid, 2-hydroxy-, (3Z)-3-hexenyl ester
Benzoic acid, 2-hydroxy-, 3-hexenyl ester, (Z)-
Salicylic acid, 3-hexen-1-yl ester
2-Hydroxybenzoic acid, (Z)-3-hexenyl ester
(Z)-3-Hexenyl salicylate
EINECS 265-745-8
beta,gamma-cis-Hexenyl salicylate
UNII-C78Y9OR6YH
SID26757650
cis-3-Hexenyl salicylic acid
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
SCIL (9/2019)
IFRA Transparency
consumer_product
Europe
Australian Status
AICIS status: listed
Frequently Asked Questions
Is cis-3-Hexenyl Salicylate allowed in the EU?
cis-3-Hexenyl Salicylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does cis-3-Hexenyl Salicylate do in cosmetics?
cis-3-Hexenyl Salicylate functions as: Fragrance ingredient with green, herbal, slightly medicinal profile. It is classified as a cosmetic ingredient in our database. CAS number: 65405-77-8.
What is the NOAEL for cis-3-Hexenyl Salicylate?
The NOAEL (No Observed Adverse Effect Level) for cis-3-Hexenyl Salicylate is =200 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is cis-3-Hexenyl Salicylate used outside cosmetics?
cis-3-Hexenyl Salicylate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check cis-3-Hexenyl Salicylate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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