What is the NOAEL for Hexamidine diisethionate?
Hexamidine diisethionate has 4 NOAEL studies in the database. The lowest reported value is 023XA5Z50L UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Hexamidine diisethionate
Also known as: Ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-[1,6-hexanediylbis(oxy)]bis[benzenecarboximidamide] (2:1), Benzamidine, 4,4'-(hexamethylenedioxy)di-, diisethionate, EINECS No.: 211-533-5, Ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(hexamethylenedioxy)dibenzamidine (2:1), Ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(hexamethylenedioxy)dibenzamidine (+14 more)
CAS 659-40-5
Hexamidine diisethionate (CAS 659-40-5) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Hexamidine diisethionate
CAS Number
659-40-5
DTXSID
DTXSID60984372
Molecular Formula
C20H26N4O2.2C2H6O4S
InChI Key
NBVZMBLJRHUOJR-UHFFFAOYSA-N
Monoisotopic Mass
606.202936
Synonyms
Ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-[1,6-hexanediylbis(oxy)]bis[benzenecarboximidamide] (2:1)Benzamidine, 4,4'-(hexamethylenedioxy)di-, diisethionateEINECS No.: 211-533-5Ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(hexamethylenedioxy)dibenzamidine (2:1)Ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(hexamethylenedioxy)dibenzamidineBenzamidine, 4,4'-(hexamethylenedioxy)di-, bis(2-hydroxyethanesulfonate)Benzenecarboximidamide, 4,4'-[1,6-hexanediylbis(oxy)]bis-, bis(2-hydroxyethanesulfonate)2535RPDesomedineElastab HP 100Elestab HP 100Esomedina
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
9 records
Softener and conditionerPreservativeDefoamerBiocide
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 023XA5Z50L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 023XA5Z50L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 023XA5Z50L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 023XA5Z50L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-hydroxyethanesulphonic acid, compound with 4,4'-[hexane-1,6-diylbis(oxy)]bis[benzenecarboxamidine] (2:1) | 211-533-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.1%
Category
Preservatives
Frequently Asked Questions
What regulatory lists include Hexamidine diisethionate?
Hexamidine diisethionate appears on 1 regulatory/inventory list including active_ingredient; Europe; Pesticides. Source: EPA CPDat.
Is Hexamidine diisethionate used in cosmetics?
Yes, Hexamidine diisethionate is also indexed as a cosmetic ingredient under the name Hexamidine Diisethionate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Hexamidine diisethionate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is Hexamidine diisethionate used outside industrial chemicals?
Hexamidine diisethionate also appears in cosmetics databases.